Ye Xiaobu, Itzoe MariaLisa, Sarabia-Estrada Rachel, DeTolla Louis, Tyler Betty M, Guarnieri Michael
Department of Neurological Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA.
School of Medicine, Departments of Pathology, Medicine, Epidemiology and Public Health and the Program of Comparative Medicine, University of Maryland, Baltimore, MD, USA.
J Vet Med. 2018 May 9;2018:9562803. doi: 10.1155/2018/9562803. eCollection 2018.
Studies have demonstrated that buprenorphine, a front line drug for veterinary analgesia, may alleviate symptoms of chronic pain. A cage side observation protocol was used to record behavioral signs in a mouse clinical trial of extended release buprenorphine. A retrospective review of the observations for signs of pain and stress revealed that mice given a fivefold overdose of buprenorphine (16.25 mg/kg) showed lethargy and facial signs associated with stress. However, similar signs were observed in the drug-free control mice as early as Day 3 of single-cage housing. This appears to be the first report of cage effects in a clinical trial for a veterinary drug.
研究表明，丁丙诺啡作为兽医镇痛的一线药物，可能会缓解慢性疼痛症状。在一项关于丁丙诺啡缓释剂的小鼠临床试验中，采用笼边观察方案来记录行为体征。对疼痛和应激体征观察结果的回顾性分析显示，给予五倍过量丁丙诺啡（16.25毫克/千克）的小鼠出现嗜睡和与应激相关的面部体征。然而，早在单笼饲养的第3天，在无药物对照组小鼠中就观察到了类似的体征。这似乎是关于兽药临床试验中笼养效应的首次报告。
