Sunkara Tagore, Sharma Santosh R, Ofosu Andrew, Gaduputi Vinaya, Reddy Madhavi, Shahzad Ghulamullah
The Brooklyn Hospital Center, Clinical Affiliate of the Mount Sinai Hospital, Brooklyn, NY, USA.
SBH Health System, Bronx, NY, USA.
J Investig Med High Impact Case Rep. 2018 May 24;6:2324709618777003. doi: 10.1177/2324709618777003. eCollection 2018 Jan-Dec.
Multiple myeloma (MM), a plasma cell tumor, is primarily a disease of the bone marrow. Extramedullary plasmacytoma, also a plasma cell tumor, is very rare in the gastrointestinal tract and the pancreas, and only a handful cases have been documented till now. Gastric and pancreatic plasmacytomas are usually seen in elderly patients; however, cases in patients as young as 32 years of age have been reported. Commonly, patients with gastric plasmacytoma present with nonspecific symptoms like epigastric pain, abdominal fullness, anorexia, and weight loss, or serious conditions like massive upper gastrointestinal bleeding and gastric outlet obstruction. Patients with pancreatic plasmacytoma commonly present with obstructive jaundice. In this article, we present the case of a 79-year-old man with a history of MM for 3 years, diagnosed with gastric and pancreatic masses, which turned out to be plasmacytomas. To our knowledge, simultaneous occurrence of gastric and pancreatic plasmacytomas is extremely uncommon with less than 5 cases reported in the literature. We also compiled all the individual cases of gastric and pancreatic MM that have been reported in literature till now.
多发性骨髓瘤（MM）是一种浆细胞肿瘤，主要是一种骨髓疾病。髓外浆细胞瘤也是一种浆细胞肿瘤，在胃肠道和胰腺中非常罕见，迄今为止仅有少数病例被记录。胃和胰腺浆细胞瘤通常见于老年患者；然而，也有报道称最年轻32岁的患者也会出现这种情况。通常，胃浆细胞瘤患者表现为上腹部疼痛、腹胀、厌食和体重减轻等非特异性症状，或出现大量上消化道出血和胃出口梗阻等严重情况。胰腺浆细胞瘤患者通常表现为梗阻性黄疸。在本文中，我们报告了一例79岁男性患者，有3年MM病史，被诊断为胃和胰腺肿块，结果证实为浆细胞瘤。据我们所知，胃和胰腺浆细胞瘤同时发生极为罕见，文献报道不足5例。我们还汇总了迄今为止文献中报道的所有胃和胰腺MM的个别病例。
