Oliva Stefania, Gambella Manuela, Boccadoro Mario, Bringhen Sara
a Myeloma Unit, Division of Hematology , University of Torino, Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino , Torino , Italy.
Expert Opin Biol Ther. 2017 Nov;17(11):1375-1387. doi: 10.1080/14712598.2017.1364359. Epub 2017 Aug 10.
The multiple myeloma (MM) treatment scenario has changed considerably over the past few years. Several novel targeted therapies are currently under consideration including oncolytic virotherapy. Areas covered: This review provides an analysis of the mechanisms of action of virotherapy, and summarizes the preclinical and clinical studies of systemic virotherapy developed for the treatment of MM. Different types of viruses have been identified, including: adenovirus, vaccinia virus, herpes simplex virus 1, myxoma virus, reovirus, measles virus, vesicular stomatitis virus and coxsackievirus A21. Expert opinion: The above-mentioned viruses can do more than simply infect and kill malignant plasma cells alone or in combination with chemo and/or radiotherapy. In fact, some of them can also be used to purge myeloma cells from an autologous bone marrow (BM) transplant. Further investigations are required to better explore the best therapeutic combinations for MM and to also overcome antiviral response immunity that can limit the efficacy of this therapeutic strategy.
在过去几年中，多发性骨髓瘤（MM）的治疗情况发生了很大变化。目前正在考虑几种新型靶向疗法，包括溶瘤病毒疗法。涵盖领域：本综述分析了病毒疗法的作用机制，并总结了为治疗MM而开发的全身病毒疗法的临床前和临床研究。已鉴定出不同类型的病毒，包括：腺病毒、痘苗病毒、单纯疱疹病毒1型、黏液瘤病毒、呼肠孤病毒、麻疹病毒、水疱性口炎病毒和柯萨奇病毒A21。专家意见：上述病毒不仅可以单独或与化疗和/或放疗联合感染并杀死恶性浆细胞。事实上，其中一些病毒还可用于从自体骨髓（BM）移植中清除骨髓瘤细胞。需要进一步研究以更好地探索MM的最佳治疗组合，并克服可能限制这种治疗策略疗效的抗病毒反应免疫。
