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本文引用的文献

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Combined BRAF, EGFR, and MEK Inhibition in Patients with -Mutant Colorectal Cancer.BRAF、EGFR 和 MEK 联合抑制治疗 - 突变型结直肠癌患者。
Cancer Discov. 2018 Apr;8(4):428-443. doi: 10.1158/2159-8290.CD-17-1226. Epub 2018 Feb 5.
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Wnt/β-Catenin Pathway Activation Mediates Adaptive Resistance to BRAF Inhibition in Colorectal Cancer.Wnt/β-连环蛋白通路激活介导结直肠癌对 BRAF 抑制的适应性耐药。
Mol Cancer Ther. 2018 Apr;17(4):806-813. doi: 10.1158/1535-7163.MCT-17-0561. Epub 2017 Nov 22.
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Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities.Wnt/β-连环蛋白信号通路、疾病与新兴治疗模式。
Cell. 2017 Jun 1;169(6):985-999. doi: 10.1016/j.cell.2017.05.016.
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Wnt/β-catenin signaling and AXIN1 regulate apoptosis triggered by inhibition of the mutant kinase BRAFV600E in human melanoma.Wnt/β-catenin 信号通路和 AXIN1 调控 BRAFV600E 突变激酶抑制剂诱导的人黑色素瘤细胞凋亡。
Sci Signal. 2012 Jan 10;5(206):ra3. doi: 10.1126/scisignal.2002274.
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Inhibition of mutated, activated BRAF in metastatic melanoma.转移性黑色素瘤中突变激活 BRAF 的抑制。
N Engl J Med. 2010 Aug 26;363(9):809-19. doi: 10.1056/NEJMoa1002011.
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Activated Wnt/beta-catenin signaling in melanoma is associated with decreased proliferation in patient tumors and a murine melanoma model.黑色素瘤中激活的Wnt/β-连环蛋白信号传导与患者肿瘤及小鼠黑色素瘤模型中的增殖减少有关。
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1193-8. doi: 10.1073/pnas.0811902106. Epub 2009 Jan 14.

Targeting parallel bypass signaling to combat adaptive resistance to BRAF inhibition in colorectal cancer.

作者信息

Gao Chenxi, Hu Jing

机构信息

Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

出版信息

Oncoscience. 2018 Apr 29;5(3-4):57-58. doi: 10.18632/oncoscience.401. eCollection 2018 Mar.

DOI:10.18632/oncoscience.401
PMID:29854868
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5978442/
Abstract
摘要