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骨折与自杀风险增加:基于人群的病例对照研究。

Fractures and the increased risk of suicide: a population-based case-control study.

机构信息

General Institute of Medical Science, National Defense Medical Center and Department of Radiology, Tri-Service General Hospital, Taipei, Taiwan.

School of Pharmacy, Institute of Clinical Pharmacy and Pharmaceutical Sciences, National Cheng Kung University, Tainan, Taiwan.

出版信息

Bone Joint J. 2018 Jun 1;100-B(6):780-786. doi: 10.1302/0301-620X.100B6.BJJ-2017-1183.R2.

Abstract

AIMS

A high rate of suicide has been reported in patients who sustain fractures, but the association remains uncertain in the context of other factors. The aim of this study was to examine the association between fractures and the risk of suicide in this contextual setting.

PATIENTS AND METHODS

We performed a case-control study of patients aged 40 years or older who died by suicide between 2000 and 2011. We included patients' demographics, physical and mental health problems, and socioeconomic factors. We performed conditional logistic regression to evaluate the associations between fractures and the risk of suicide.

RESULTS

We included a total of 34 794 patients who died by suicide and 139 176 control patients. We found that fractures as a homogenous group (adjusted odds ratios (aOR), 1.48; 95% confidence interval (CI) 1.43 to 1.53), and specifically pelvic (aOR 2.04; 95% CI 1.68 to 2.47) and spinal fractures (aOR 1.53; 95% CI 1.43 to 1.64), were associated with a higher risk of suicide. In addition, we found that patients who had a lower income, had never married, had lower levels of educational attainment, or had coexistent physical and mental conditions such as anxiety, mood disorders, and psychosis-related disorders had a higher risk of suicide.

CONCLUSION

Fractures, specifically those of the hip and spine, were associated with an increased risk of suicide. The findings suggest that greater clinical attention should be given to this risk in patients with fractures, especially for those with additional risk factors. Cite this article: Bone Joint J 2018;100-B:780-6.

摘要

目的

有报道称,骨折患者的自杀率很高,但在其他因素的背景下,这种关联仍不确定。本研究旨在检查这种背景下骨折与自杀风险之间的关联。

患者与方法

我们对 2000 年至 2011 年间自杀死亡的年龄在 40 岁或以上的患者进行了病例对照研究。我们纳入了患者的人口统计学、身体和心理健康问题以及社会经济因素。我们采用条件逻辑回归来评估骨折与自杀风险之间的关联。

结果

我们共纳入了 34794 名自杀死亡患者和 139176 名对照患者。我们发现,骨折作为一个同质组(校正比值比(aOR),1.48;95%置信区间(CI)1.43 至 1.53),特别是骨盆(aOR 2.04;95%CI 1.68 至 2.47)和脊柱骨折(aOR 1.53;95%CI 1.43 至 1.64),与自杀风险增加相关。此外,我们发现收入较低、从未结婚、教育程度较低或同时存在焦虑、心境障碍和精神病相关障碍等身体和心理健康问题的患者自杀风险更高。

结论

骨折,特别是髋部和脊柱骨折,与自杀风险增加相关。这些发现表明,在骨折患者中,应更加关注这一风险,特别是对那些存在其他风险因素的患者。

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