Department of Psychiatry, Chang Gung Medical Foundation, Chiayi Chang Gung Memorial Hospital, Taiwan; School of Medicine, Chang Gung University, Taiwan.
Department of Public Health, College of Health Science, Kaohsiung Medical University, Kaohsiung, Taiwan.
Gen Hosp Psychiatry. 2018 Jan-Feb;50:45-50. doi: 10.1016/j.genhosppsych.2017.09.008. Epub 2017 Sep 29.
Diseases of the pancreas, especially pancreatitis, have been implicated as possible risk factors for psychiatric illnesses, such as depression and anxiety disorder. This nested case-control study aimed to investigate the association between diseases of the pancreas and completed suicide in a psychiatric population-based study.
The case group comprised 6568 completed suicides (ICD-9: E950-E959, E980-989) patients from the national mortality database between January 1, 2002 and December 1, 2010. These cases were compared with 6568 gender-, age-, residence-, and insurance premium-matched controls. Both suicide and non-suicide study patients were drawn from a group with previous psychiatric diagnoses. The risk of suicide among patients with diseases of the pancreas was analyzed using a conditional logistic regression model that controlled for alcohol-related disorder, drug dependence, schizophrenia, depressive disorder, bipolar disorder, anxiety disorder, Charlson comorbidity score, and outpatient visits.
Disease of the pancreas was an independent risk factor for psychiatric patients who had completed suicide when adjusted for clinical and other comorbid factors. Among these covariates, alcohol-related disorders partially mediate the suicide risk among patients with disease of the pancreas, and mental disorders may not mediate this suicide risk.
Diseases of the pancreas were associated with increased risk of completed suicide after controlling for potential confounding factors.
胰腺疾病，尤其是胰腺炎，已被认为是精神疾病（如抑郁症和焦虑障碍）的可能危险因素。本巢式病例对照研究旨在调查胰腺疾病与精神科人群中自杀完成情况之间的关联。
病例组包括 2002 年 1 月 1 日至 2010 年 12 月 1 日期间全国死亡率数据库中 ICD-9 编码为 E950-E959、E980-989 的 6568 例自杀患者。这些病例与 6568 名性别、年龄、居住地和保险费匹配的对照进行比较。自杀和非自杀研究患者均来自有既往精神科诊断的人群。使用条件逻辑回归模型分析了胰腺疾病患者自杀的风险，该模型控制了酒精相关障碍、药物依赖、精神分裂症、抑郁症、双相情感障碍、焦虑障碍、Charlson 合并症评分和门诊就诊情况。
在调整了临床和其他合并症因素后，胰腺疾病是精神科患者自杀的独立危险因素。在这些混杂因素中，酒精相关障碍部分介导了胰腺疾病患者的自杀风险，而精神障碍可能不会介导这种自杀风险。
在控制潜在混杂因素后，胰腺疾病与自杀完成风险增加相关。
