中国西北伊犁地区维吾尔族人群18个常染色体STR基因座的遗传多样性及系统发育分析
Genetic diversities and phylogenetic analysis of 18 autosomal STR loci in the Uyghur population living in Ili, Northwest China.
作者信息
Li Zhenghui, Zhang Jian, Zhang Yiwen, Kang Bin, Li Wanshui, Zhao Xingchun, Lin Ziqing, Ye Jian
机构信息
Department of Forensic Medicine, Criminal Investigation Police University of China, No. 83, Tawan Street, Huanggu District, Shenyang, 110854, Liaoning, China.
Institute of Forensic Science, Ministry of Public Security, Beijing, 100038, China.
出版信息
Int J Legal Med. 2019 May;133(3):771-773. doi: 10.1007/s00414-018-1872-y. Epub 2018 May 31.
Ili is located in northernmost Xinjiang, China. The Uyghur population only accounts for 15.90% of the total population in the nation. There is currently no large population data-based data set in Ili Uyghur. In this study, we investigated the genetic diversities of 18 autosomal short tandem repeat (STR) loci in 1129 Uyghur individuals living in Ili. The values of combined power of discrimination (CPD) and combined probability of exclusion (CPE) were 0.99999999999999999999990244 and 0.99999995645, respectively. Furthermore, we explored the genetic relationships between the Ili Uyghur population and 32 previously published populations. The results indicated that the Ili Uyghur population was more closely related to the Xinjiang Kazakh population. In addition, It was worth noting that significant differences were observed between Ili the Uyghur population and the Uyghur1 and Uyghur2 populations at the shared 15 loci, with significant differences at 7 and 11 loci after Bonferroni adjustment (p = 0.05/495 ≈ 0.00010).
伊犁位于中国新疆最北部。维吾尔族人口仅占全国总人口的15.90%。目前伊犁维吾尔族尚无基于大样本数据的数据集。在本研究中，我们调查了居住在伊犁的1129名维吾尔族个体中18个常染色体短串联重复序列（STR）位点的遗传多样性。鉴别力联合概率（CPD）和排除联合概率（CPE）值分别为0.99999999999999999999990244和0.99999995645。此外，我们探讨了伊犁维吾尔族群体与32个先前发表的群体之间的遗传关系。结果表明，伊犁维吾尔族群体与新疆哈萨克族群体关系更为密切。此外，值得注意的是，在15个共享位点上，伊犁维吾尔族群体与维吾尔族1和维吾尔族2群体之间存在显著差异，经Bonferroni校正后，在7个和11个位点上存在显著差异（p = 0.05/495 ≈ 0.00010）。
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