Cracolici Vincent, Gurbuxani Sandeep, Ginat Daniel T
Department of Pathology, University of Chicago, Chicago, IL, USA.
Department of Radiology, University of Chicago, 5841 S Maryland Avenue, Chicago, IL, 60637, USA.
Head Neck Pathol. 2019 Dec;13(4):656-660. doi: 10.1007/s12105-018-0941-3. Epub 2018 May 31.
Sinus histiocytosis with massive lymphadenopathy, or Rosai-Dorfman disease, is a rare, benign type of non-Langerhans cell histiocytosis. The radiological findings are often nonspecific, potentially mimicking malignancies. The diagnosis is ultimately made based on pathology, in which the lymph nodes are characterized by a dilated subcapsular sinus filled with histiocytes that can exhibit emperipolesis. Immunohistochemically, the histiocytes are variably CD68 positive and reliably negative for CD1a. The features of head and neck sinus histiocytosis with massive lymphadenopathy are exemplified in this radiology-pathology correlation sine qua non article.
伴巨大淋巴结病的窦性组织细胞增生症，即罗萨伊-多夫曼病，是一种罕见的良性非朗格汉斯细胞组织细胞增生症。其影像学表现通常不具有特异性，可能类似恶性肿瘤。最终诊断基于病理学检查，其中淋巴结的特征为包膜下窦扩张，充满可表现为吞噬现象的组织细胞。免疫组织化学检查显示，组织细胞CD68呈不同程度阳性，而CD1a呈可靠阴性。这篇必不可少的放射学-病理学相关性文章举例说明了头颈部伴巨大淋巴结病的窦性组织细胞增生症的特征。
