Kumar Bipin, Karki Smriti, Paudyal Punam
Department of Pathology, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
Diagn Cytopathol. 2008 Oct;36(10):691-5. doi: 10.1002/dc.20904.
Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) is a rare benign disease of unknown etiology presenting with massive lymphadenopathy. We report four cases of this disease retrieved from the archives of cytopathology laboratory, BPKIHS, Dharan, Nepal, during the period of January 2002 to October 2007. The cytologic morphology revealed lymphocytes, plasma cells, and single to multinucleated histiocytes with well preserved lymphocytes in their cytoplasm (emperipolesis or lymphophagocytosis). It is concluded that FNAC is a useful and reliable tool for the diagnosis of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease) and biopsy can be avoided in these patients, thereby reducing patient inconvenience and health care cost.
伴有巨大淋巴结病的窦组织细胞增生症（罗萨伊 - 多夫曼病）是一种病因不明的罕见良性疾病，表现为巨大淋巴结病。我们报告了2002年1月至2007年10月期间从尼泊尔达兰BPKIHS细胞病理学实验室档案中检索到的4例该疾病。细胞学形态显示淋巴细胞、浆细胞以及单核至多核组织细胞，其细胞质内淋巴细胞保存良好（血细胞吞噬或淋巴细胞吞噬）。结论是，细针穿刺抽吸活检（FNAC）是诊断伴有巨大淋巴结病的窦组织细胞增生症（罗萨伊 - 多夫曼病）的一种有用且可靠的工具，这些患者可避免活检，从而减少患者的不便和医疗费用。
