Yhnell Emma, Heuer Andreas
Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, Wales, UK.
Molecular Neuromodulation, Experimental Medicine, Lund University, Lund, Sweden.
Methods Mol Biol. 2018;1780:143-162. doi: 10.1007/978-1-4939-7825-0_8.
Huntington's disease (HD) presents clinically with a triad of motor, cognitive, and psychiatric symptoms. Cognitive symptoms often occur early within the disease progression, prior to the onset of motor symptoms, and they are significantly burdensome to people who are affected by HD. In order to determine the suitability of mouse models of HD in recapitulating the human condition, these models must be behaviorally tested and characterized. Operant behavioral testing offers an automated and objective method of behaviorally profiling motor, cognitive, and psychiatric dysfunction in HD mice. Furthermore, operant testing can also be employed to determine any behavioral changes observed after any associated interventions or experimental therapeutics. We here present an overview of the most commonly used operant behavioral tests to dissociate motor, cognitive, and psychiatric aspects of mouse models of HD.
亨廷顿舞蹈症（HD）临床上表现为运动、认知和精神症状三联征。认知症状通常在疾病进展早期、运动症状出现之前就已出现，并且给HD患者带来极大负担。为了确定HD小鼠模型在模拟人类病情方面的适用性，必须对这些模型进行行为测试和特征描述。操作性行为测试提供了一种自动化且客观的方法，用于对HD小鼠的运动、认知和精神功能障碍进行行为分析。此外，操作性测试还可用于确定在任何相关干预或实验性治疗后观察到的行为变化。我们在此概述了最常用的操作性行为测试，以区分HD小鼠模型的运动、认知和精神方面。
