评估和调节亨廷顿舞蹈病中犬尿氨酸途径的动态变化：聚焦于犬尿氨酸3-单加氧酶
Assessing and Modulating Kynurenine Pathway Dynamics in Huntington's Disease: Focus on Kynurenine 3-Monooxygenase.
作者信息
Sathyasaikumar Korrapati V, Breda Carlo, Schwarcz Robert, Giorgini Flaviano
机构信息
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA.
Department of Genetics and Genome Biology, University of Leicester, Leicester, UK.
出版信息
Methods Mol Biol. 2018;1780:397-413. doi: 10.1007/978-1-4939-7825-0_18.
The link between disturbances in kynurenine pathway (KP) metabolism and Huntington's disease (HD) pathogenesis has been explored for a number of years. Several novel genetic and pharmacological tools have recently been developed to modulate key regulatory steps in the KP such as the reaction catalyzed by the enzyme kynurenine 3-monooxygenase (KMO). This insight has offered new options for exploring the mechanistic link between this metabolic pathway and HD, and provided novel opportunities for the development of candidate drug-like compounds. Here, we present an overview of the field, focusing on some novel approaches for interrogating the pathway experimentally.
犬尿氨酸途径（KP）代谢紊乱与亨廷顿舞蹈病（HD）发病机制之间的联系已被研究多年。最近开发了几种新型遗传和药理学工具，以调节KP中的关键调控步骤，如犬尿氨酸3-单加氧酶（KMO）催化的反应。这一见解为探索该代谢途径与HD之间的机制联系提供了新的选择，并为开发候选药物样化合物提供了新的机会。在这里，我们概述了该领域，重点介绍了一些通过实验探究该途径的新方法。
Zotero 插件