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犬尿氨酸-3-单加氧酶：不同疾病治疗的新方向。

Kynurenine-3-monooxygenase: A new direction for the treatment in different diseases.

作者信息

Lu Yifei, Shao Mingmei, Wu Tao

机构信息

Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese Medicine Shanghai China.

出版信息

Food Sci Nutr. 2020 Jan 20;8(2):711-719. doi: 10.1002/fsn3.1418. eCollection 2020 Feb.

DOI:10.1002/fsn3.1418
PMID:32148781
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7020307/
Abstract

Kynurenine-3-monooxygenase (KMO) is an enzyme that relies on nicotinamide adenine dinucleotide phosphate (NADP), a key site in the kynurenine pathway (KP), which has great effects on neurological diseases, cancer, and peripheral inflammation. This review mainly pay attention to the research of KMO mechanism for the treatment of different diseases, and hopes to provide assistance for clinical and drug use. KMO controlling the chief division of the KP, which directly controls downstream product quinolinic acid (QUIN) and indirectly controls kynurenic acid (KYNA), plays an important role in many diseases, especially neurological diseases.

摘要

犬尿氨酸-3-单加氧酶（KMO）是一种依赖于烟酰胺腺嘌呤二核苷酸磷酸（NADP）的酶，它是犬尿氨酸途径（KP）中的一个关键位点，对神经疾病、癌症和外周炎症有很大影响。本综述主要关注KMO治疗不同疾病的机制研究，希望为临床和药物使用提供帮助。KMO控制着KP的主要分支，直接控制下游产物喹啉酸（QUIN）并间接控制犬尿酸（KYNA），在许多疾病尤其是神经疾病中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4564/7020307/cc393f065552/FSN3-8-711-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4564/7020307/26151dedc2b0/FSN3-8-711-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4564/7020307/cc393f065552/FSN3-8-711-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4564/7020307/26151dedc2b0/FSN3-8-711-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4564/7020307/cc393f065552/FSN3-8-711-g002.jpg

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