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与患者谈论生物类似药。

Talking to patients about biosimilars.

机构信息

Gastrointestinal Oncology Service, Memorial Sloan Kettering Cancer Center & Weill Cornell Medical College, New York, NY 10065, USA.

Istituto di Scienze Farmacologiche della Svizzera Italiana (ISFSI), Servizio Centrale di Farmacia, Lugano, Switzerland.

出版信息

Future Oncol. 2018 Oct;14(23):2403-2414. doi: 10.2217/fon-2018-0044. Epub 2018 Jun 1.

Abstract

Biologic therapies target aberrant pathways in diseases including diabetes, cancer and autoimmune disorders. Despite recent scientific advances, patient access to these agents can be limited. Biosimilars are designed to be highly similar to the originator biologic, targeting the same biological pathways, with comparable efficacy and safety. Biosimilars have the advantage of lower treatment costs, offering the potential for increased clinical use and patient access. Several biosimilars are approved for clinical use in the USA and Europe; however, there is a lack of awareness about biosimilars among healthcare providers and patients. This overview of the scientific basis of biosimilars and current indications aim to enhance discussions with patients and increase understanding of the role of biosimilars in individual treatment plans.

摘要

生物制剂针对包括糖尿病、癌症和自身免疫性疾病在内的疾病中的异常途径。尽管最近取得了科学进展,但患者获得这些药物的机会可能有限。生物类似药的设计目的是与原创生物制剂高度相似,针对相同的生物途径,具有相当的疗效和安全性。生物类似药具有治疗成本较低的优势,有可能增加临床应用和患者获得药物的机会。有几种生物类似药已获准在美国和欧洲临床使用;然而,医疗保健提供者和患者对生物类似药的认识不足。本文概述了生物类似药的科学基础和目前的适应证,旨在促进与患者的讨论,并提高对生物类似药在个体化治疗计划中的作用的理解。

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