Department of Structural and Functional Biology, Obesity and Comorbidities Research Center (OCRC), Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
J Cell Physiol. 2018 Nov;233(11):8477-8481. doi: 10.1002/jcp.26829. Epub 2018 Jun 1.
The cellular cytoskeleton is involved with multiple biological processes and is tightly regulated by multiple proteins and effectors. Among these, the RhoGTPases family is one of the most important players. RhoGTPAses are, in turn, regulated by many other elements. In the past decade, one of those regulators, the RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21), has been overlooked, despite being implied as having an important role on many of those processes. In this paper, we aimed to review the available literature regarding ARHGAP21 to highlight its importance and the mechanisms of action that have been found so far for this still unknown protein involved with cell adhesion, migration, Golgi regulation, cell trafficking, and even insulin secretion.
细胞骨架参与多种生物学过程，并受到多种蛋白质和效应物的严格调控。其中，RhoGTPases 家族是最重要的参与者之一。RhoGTPases 又受到许多其他因素的调节。在过去的十年中，尽管 RhoGAP Rho GTPase Activating Protein 21 (ARHGAP21) 被暗示在许多这些过程中具有重要作用，但它一直被忽视。在本文中，我们旨在回顾有关 ARHGAP21 的现有文献，以强调其重要性和迄今为止发现的这种参与细胞黏附、迁移、高尔基体调节、细胞运输甚至胰岛素分泌的未知蛋白质的作用机制。
