Department of Nutrition, Exercise, and Sports, Faculty of Sciences, University of Copenhagen, 1958 Frederiksberg C, Denmark; email:
Gelesis Inc., Boston, Massachusetts 02116, USA; email:
Annu Rev Nutr. 2018 Aug 21;38:245-272. doi: 10.1146/annurev-nutr-082117-051606. Epub 2018 Jun 1.
During the past several decades, numerous trials have compared various diets for the management of overweight and obesity, assuming that a single dietary strategy would be appropriate for all individuals. These studies have failed to provide strong evidence for the efficacy of any particular diet, and it is likely that different people will have different levels of success on different diets. We identified studies investigating pretreatment glycemia or insulinemia status, or both, of the individual as prognostic markers of weight loss during periods in which the composition of a participant's diet was known. Overall, research suggests that providing specific diets for weight management based on pretreatment glycemia and insulinemia statuses holds great promise for advancing personalized nutrition.
在过去的几十年中，许多试验比较了各种饮食策略在超重和肥胖管理中的效果，假设单一的饮食策略适用于所有个体。这些研究未能为任何特定饮食的疗效提供有力证据，而且不同人在不同饮食上可能会有不同程度的成功。我们确定了研究个体治疗前血糖或胰岛素水平或两者作为体重减轻的预后标志物的研究，在此期间已知参与者饮食的组成。总的来说，研究表明，根据治疗前血糖和胰岛素水平为体重管理提供特定饮食具有很大的推进个性化营养的潜力。
