Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, P.O. Box 5000, Oulu 90014, Finland; Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland.
Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland; Center for Life Course Health Research, University of Oulu, P.O. Box 5000, Oulu 90014, Finland.
Diabetes Res Clin Pract. 2018 Aug;142:110-119. doi: 10.1016/j.diabres.2018.05.035. Epub 2018 May 30.
We investigated the association of impaired glucose metabolism with tooth loss in adults in the Northern Finland Birth Cohort Study 1966 (NFBC1966).
We examined 4394 participants from the 46-year follow-up of the NFBC1966. Self-reported number of teeth as well as insulin and glucose values, taken during a standard oral glucose tolerance test (OGTT), served as the primary study variables. A multinomial logistic regression model served to analyse (unadjusted, smoking-adjusted and fully adjusted) the association between number of teeth (0-24, 25-27, 28-32) and glucose metabolism in women and men.
Among women, type 2 diabetes - whether previously known or detected during screening - pointed to a higher likelihood of 0-24 teeth (fully adjusted OR = 2.99, 95%CI = 1.54-5.80) and 25-27 teeth (OR = 1.91, 95%CI = 1.18-3.08) than did normal glucose tolerance. Similarly, impaired fasting glucose and impaired glucose tolerance together indicated a higher likelihood of 0-24 teeth (OR = 1.71, 95%CI = 1.09-2.69) than did normal glucose tolerance. A similar, statistically non-significant, pattern emerged among men. Number of teeth associated with OGTT insulin and glucose curves as well as with the Matsuda index in both women and men.
Tooth loss strongly associated with impaired glucose metabolism in middle-aged Finnish women.
我们在 1966 年芬兰北部出生队列研究（NFBC1966）中调查了成年人葡萄糖代谢受损与牙齿缺失的关系。
我们检查了 NFBC1966 46 年随访的 4394 名参与者。自我报告的牙齿数量以及在标准口服葡萄糖耐量试验（OGTT）期间获得的胰岛素和葡萄糖值作为主要研究变量。使用多项逻辑回归模型分析（未经调整、吸烟调整和完全调整）女性和男性牙齿数量（0-24、25-27、28-32）与葡萄糖代谢之间的关系。
在女性中，无论是否已知患有 2 型糖尿病或在筛查期间发现，都表明发生 0-24 颗牙齿（完全调整后的 OR=2.99，95%CI=1.54-5.80）和 25-27 颗牙齿（OR=1.91，95%CI=1.18-3.08）的可能性更高，而正常葡萄糖耐量则较低。同样，空腹血糖受损和葡萄糖耐量受损一起表明发生 0-24 颗牙齿（OR=1.71，95%CI=1.09-2.69）的可能性高于正常葡萄糖耐量。在男性中也出现了类似的、统计学上无显著性的模式。在女性和男性中，牙齿数量与 OGTT 胰岛素和葡萄糖曲线以及 Matsuda 指数相关。
在中年芬兰女性中，牙齿缺失与葡萄糖代谢受损密切相关。
