Escrivá F, Rodríguez C, Pascual-Leone A M
J Neurochem. 1985 May;44(5):1358-62. doi: 10.1111/j.1471-4159.1985.tb08770.x.
The effect of undernutrition from the 16th day of pregnancy up to 70th day of life on blood glucose and ketone bodies and on several brain mitochondrial enzymes related to energy metabolism or biosynthetic function was investigated. Undernutrition in perinatal period was established by means of a food restriction to pregnant rats and, later, to the lactating mother; undernourished postweaned rats received half the diet consumed by the controls. Body and brain weight from undernourished rats was less than controls throughout the entire period studied. Glycemia and ketonemia were also always lower than controls. Cytochrome c oxidase, citrate synthase, 3-hydroxybutyrate dehydrogenase, 3-oxoacid coenzyme A transferase, and acetoacetyl-coenzyme A thiolase activities during the suckling period were in most stages lower than controls; subsequently, activities in undernourished rats reached or surpassed the control values. These results could explain the "catch up" phenomenon in several ultrastructural parameters found by other authors in undernourished postweaned rats.
研究了从怀孕第16天到出生后70天的营养不良对血糖、酮体以及与能量代谢或生物合成功能相关的几种脑线粒体酶的影响。围产期营养不良是通过限制怀孕大鼠以及随后的哺乳期母鼠的食物来实现的；断奶后营养不良的大鼠摄入的食物量是对照组的一半。在整个研究期间，营养不良大鼠的体重和脑重均低于对照组。血糖和酮血症也始终低于对照组。哺乳期的细胞色素c氧化酶、柠檬酸合酶、3-羟基丁酸脱氢酶、3-氧代酸辅酶A转移酶和乙酰乙酰辅酶A硫解酶活性在大多数阶段低于对照组；随后，营养不良大鼠的这些酶活性达到或超过了对照组的值。这些结果可以解释其他作者在断奶后营养不良大鼠中发现的几种超微结构参数的“追赶”现象。
