Chase H P, Rodgerson D O, Lindsley W, Thorne T, Cheung G
Pediatr Res. 1976 Feb;10(2):102-7. doi: 10.1203/00006450-197602000-00006.
The in vivo incorporation of radioactivity from [U-14C]glucose was reduced in undernourished rat pups at ages 6, 10, and 17 days for brain lipids, and at age 10 days for brain amino acids. Brain glucose concentrations were lower at age 20 days (controls 1.58 +/- 0.26 vs. test 1.14 +/- 0.07 mumol/g) but other alterations in brain glucose, glycogen, ATP, or phosphocreatine concentrations were not found. Brain mitochondrial glutamate dehydrogenase activity was 21% and 30% lower in undernourished animals at ages 10 and 20 days, respectively. Brain mitochondrial and supernatant isocitrate dehydrogenase activities and pyruvate kinase activity were similar for undernourished and control animals. Brain glycogen levels were 2-4 times higher in late fetal and newborn control animals (13.6 and 15.3 mumol/g) than in older animals (4.2-5.7 mumol/g). Brain glucose, ATP, and phosphocreatine levels increased from the 15-day fetus to the newborn, but thereafter showed no further increase.
在6日龄、10日龄和17日龄的营养不良幼鼠中，脑脂质对[U-14C]葡萄糖放射性的体内掺入减少，在10日龄时脑氨基酸对其掺入也减少。20日龄时脑葡萄糖浓度较低（对照组1.58±0.26对试验组1.14±0.07μmol/g），但未发现脑葡萄糖、糖原、ATP或磷酸肌酸浓度的其他变化。在10日龄和20日龄时，营养不良动物的脑线粒体谷氨酸脱氢酶活性分别降低21%和30%。营养不良动物和对照动物的脑线粒体及上清液异柠檬酸脱氢酶活性和丙酮酸激酶活性相似。在晚期胎儿和新生对照动物中，脑糖原水平（13.6和15.3μmol/g）比年长动物（4.2 - 5.7μmol/g）高2 - 4倍。从15日龄胎儿到新生儿，脑葡萄糖、ATP和磷酸肌酸水平升高，但此后未再升高。
