Xiong Zhenchong, Yang Lin, Deng Guangzheng, Huang Xinjian, Li Xing, Xie Xinhua, Wang Jin, Shuang Zeyu, Wang Xi
Department of Breast Surgery, State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510030, China.
State Key Laboratory of Oncology in Southern China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou 510030, China.
J Clin Med. 2018 May 31;7(6):133. doi: 10.3390/jcm7060133.
Population-based estimates are lacking for the temporal trends in the contralateral breast cancer (CBC) risk for patients with breast cancer (BC). Data for BC patients diagnosed with CBC were collected from the Surveillance, Epidemiology, and End Results database. CBC incidence was calculated using the Kaplan-Meier method and the temporal trend in CBC incidence was assessed using joinpoint regression. Survival analysis was calculated using propensity scoring (PS) and multivariate Cox regression with a competing risk model. We found that 10,944 of 212,630 patients with early-stage BC were subsequently diagnosed with secondary BC in the contralateral breast. The 5-, 10-, 15-, and 20-year cumulative CBC incidences were 1.9, 4.6, 7.6, and 10.5%, respectively. Being younger (.
目前尚缺乏基于人群的乳腺癌（BC）患者对侧乳腺癌（CBC）风险随时间变化趋势的估计数据。从监测、流行病学和最终结果数据库中收集了诊断为CBC的BC患者的数据。使用Kaplan-Meier方法计算CBC发病率，并使用连接点回归评估CBC发病率的时间趋势。使用倾向评分（PS）和具有竞争风险模型的多变量Cox回归进行生存分析。我们发现，212,630例早期BC患者中有10,944例随后被诊断为对侧乳腺的继发性BC。5年、10年、15年和20年的CBC累积发病率分别为1.9%、4.6%、7.6%和10.5%。年龄较小（.
