Chen Chao, Yue Dongxu, Lei Liangyu, Wang Hairong, Lu Jia, Zhou Ya, Liu Shiming, Ding Tao, Guo Mengmeng, Xu Lin
Special Key Laboratory of Gene Detection and Therapy of Guizhou Province, Guizhou 563000, China; Department of Immunology, Zunyi Medical University, Guizhou 563000, China.
Department of Medical Physics, Zunyi Medical University, Guizhou 563000, China.
Mol Ther Nucleic Acids. 2018 Jun 1;11:508-514. doi: 10.1016/j.omtn.2018.04.003. Epub 2018 Apr 12.
The technique of targeted expression of interesting genes, including distinct delivery systems and specific gene promoter-operating expression, is an important strategy for gene therapy against cancers. Up to now, extensive literature documented the efficacy of distinct delivery systems, such as the liposome system, nano-particle system, polyetherimide (PEI) system, and so on, in cancer gene therapy. However, a related document on the potential value of using a specific gene promoter, such as a tumor suppressor, in cancer gene therapy was still scary. The main obstacle might be that the selection of an ideal gene promoter to operate interesting gene expression in cancer gene therapy is still not fully understood. Therefore, many efforts need to be done in order to make it a real power tool for the human clinical treatment of cancer patients. The purpose of this review is to clarify the current state and some problematics in development of promoter-operating targeted expression of interesting genes and highlight its potential in cancer gene therapy.
包括独特递送系统和特定基因启动子驱动表达在内的感兴趣基因的靶向表达技术，是癌症基因治疗的一项重要策略。到目前为止，大量文献记载了诸如脂质体系统、纳米颗粒系统、聚醚酰亚胺（PEI）系统等不同递送系统在癌症基因治疗中的疗效。然而，关于在癌症基因治疗中使用特定基因启动子（如肿瘤抑制基因）的潜在价值的相关文献仍然很少。主要障碍可能在于，在癌症基因治疗中选择理想的基因启动子来驱动感兴趣基因的表达仍未被充分理解。因此，为了使其成为人类临床治疗癌症患者的真正有力工具，还需要付出很多努力。本综述的目的是阐明感兴趣基因启动子驱动的靶向表达开发的现状和一些问题，并突出其在癌症基因治疗中的潜力。
