Department of Ophthalmology, The University of Tokyo, Tokyo, Japan.
Department of Ophthalmology, Kitasato University, Graduate School of Medical Sciences, Kanagawa, Japan.
Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2801-2807. doi: 10.1167/iovs.17-23485.
To investigate the structure-function mapping in the central 10° by relating Humphrey field analyzer (HFA) 10-2 visual field (VF) and circumpapillary retinal nerve fiber layer (cpRNFL) thickness from spectral-domain optical coherence tomography (SD-OCT). We also compared the obtained results with a previously reported mapping between 10-2 VF and the optic disc.
In 151 eyes of 151 POAG patients and 35 eyes from 35 healthy participants, cpRNFL thickness measurements were obtained using SD-OCT and the 10-2 VF was measured with the HFA. The relationship between visual sensitivity and cpRNL thickness values in the temporal 180° was analyzed using least absolute shrinkage and selection operator (LASSO) regression. The optic disc angle corresponding to each VF test point was then derived using the coefficients from the optimal LASSO regression.
The structure-function map obtained was largely consistent with the mapping reported previously; superior central VF test points correspond to a more vulnerable area of the optic disc, more distant toward the inferior pole from the center of the temporal quadrant (9:00 o'clock for the right eye) while inferior VF test points correspond closer to the center of the temporal quadrant. The prediction error tended to be large in the 'more vulnerable area' in the map reported previously.
The structure-function map obtained largely confirms the previously reported map; however, some important differences were observed.
通过比较 Humphrey 视野分析仪（HFA）10-2 视野（VF）和频域光相干断层扫描（SD-OCT）的周边视网膜神经纤维层（cpRNFL）厚度，探讨中央 10°的结构-功能关系。我们还将获得的结果与之前报道的 10-2VF 与视盘之间的映射进行了比较。
在 151 例 POAG 患者的 151 只眼和 35 例健康受试者的 35 只眼中，使用 SD-OCT 测量 cpRNFL 厚度，使用 HFA 测量 10-2VF。使用最小绝对收缩和选择算子（LASSO）回归分析颞侧 180°的视敏度与 cpRNL 厚度值之间的关系。然后，使用最优 LASSO 回归的系数推导出每个 VF 测试点对应的视盘角度。
得到的结构-功能图与之前报道的映射基本一致；上中央 VF 测试点对应视盘更脆弱的区域，距离颞象限（右眼 9 点）的下极更远，而下 VF 测试点更接近颞象限的中心。在之前报道的“更脆弱区域”中，预测误差往往较大。
获得的结构-功能图在很大程度上证实了之前报道的映射；然而，观察到一些重要的差异。
