慢性肾衰竭时骨骼肌细胞内的碳酸氢盐与pH值

Intracellular bicarbonate and pH of skeletal muscle in chronic renal failure.

作者信息

Guariglia A, Antonucci C, Coffrini E, Del Canale S, Fiaccadori E, Reni F, Vitali P, Arduini U, Borghetti A

出版信息

Proc Eur Dial Transplant Assoc Eur Ren Assoc. 1985;21:881-7.

Abstract

In 11 controls and 10 patients suffering from untreated uraemic acidosis intracellular bicarbonate and skeletal muscle pH (needle biopsy) were determined. In all patients a significant intracellular acidosis, not related to any extracellular indices was found. It is concluded that the chronic proton load is able to effect intracellular buffer composition; moreover the action of other factors such as derangements of cell metabolism and nutritional imbalance could be operating.

摘要

对11名对照者和10名未经治疗的尿毒症酸中毒患者测定了细胞内碳酸氢盐和骨骼肌pH值（针吸活检）。在所有患者中均发现明显的细胞内酸中毒，且与任何细胞外指标均无关联。得出的结论是，慢性质子负荷能够影响细胞内缓冲物质的组成；此外，其他因素如细胞代谢紊乱和营养失衡的作用可能也在发挥。