1,2 - 二酰甘油和佛波酯抑制激动剂诱导的人血小板中肌醇磷酸的形成：对肌醇磷脂水解负反馈调节的可能影响。
1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.
作者信息
Watson S P, Lapetina E G
出版信息
Proc Natl Acad Sci U S A. 1985 May;82(9):2623-6. doi: 10.1073/pnas.82.9.2623.
Abstract
The present study has demonstrated that pretreatment of human platelets with either phorbol ester or 1,2-diacylglycerol inhibits agonist-induced formation of inositol phosphates; this inhibition can be correlated with a decrease in the release of ATP and 5-hydroxytryptamine by thrombin. The mechanism of this action is not known, but a role for protein kinase C is suggested, as both phorbol ester and 1,2-diacylglycerol have in common the ability to activate this enzyme. These results have important implications as a possible negative feedback control over agonist-induced hydrolysis of inositol phospholipids.
摘要
本研究表明，用佛波酯或1,2 -二酰甘油预处理人血小板可抑制激动剂诱导的肌醇磷酸形成；这种抑制作用与凝血酶引起的ATP和5 -羟色胺释放减少相关。此作用机制尚不清楚，但由于佛波酯和1,2 -二酰甘油都具有激活蛋白激酶C的能力，提示蛋白激酶C起了作用。这些结果对于激动剂诱导的肌醇磷脂水解可能存在的负反馈控制具有重要意义。
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本文引用的文献
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Biochem Biophys Res Commun. 1984 May 31;121(1):386-91. doi: 10.1016/0006-291x(84)90734-4.
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Diacylglycerol and phorbol ester stimulate secretion without raising cytoplasmic free calcium in human platelets.二酰基甘油和佛波酯可刺激人血小板分泌，而不升高细胞质游离钙。
Nature. 1983;305(5932):317-9. doi: 10.1038/305317a0.
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myo-Inositol 1,4,5-trisphosphate. A second messenger for the hormonal mobilization of intracellular Ca2+ in liver.肌醇1,4,5-三磷酸。肝脏中激素动员细胞内钙离子的第二信使。
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Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.1,4,5-三磷酸肌醇促使胰腺腺泡细胞非线粒体胞内钙库释放钙离子。
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