Department of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm 141 86, Sweden.
Department of Medicine (H7), Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm 141 86, Sweden.
Cell Metab. 2018 Jul 3;28(1):45-54.e3. doi: 10.1016/j.cmet.2018.05.004. Epub 2018 May 31.
Adipocyte mobilization of fatty acids (lipolysis) is instrumental for energy expenditure. Lipolysis displays both spontaneous (basal) and hormone-stimulated activity. It is unknown if lipolysis is important for future body weight gain and associated disturbed glucose metabolism, and this was presently investigated in subcutaneous adipocytes from two female cohorts before and after ≥10-year follow-up. High basal and low stimulated lipolysis at baseline predicted future weight gain (odds ratios ≥4.6) as well as development of insulin resistance and impaired fasting glucose/type 2 diabetes (odds ratios ≥3.2). At baseline, weight gainers displayed lower adipose expression of several established lipolysis-regulating genes. Thus, inefficient lipolysis (high basal/low stimulated) involving altered gene expression is linked to future weight gain and impaired glucose metabolism and may constitute a treatment target. Finally, low stimulated lipolysis could be accurately estimated in vivo by simple clinical/biochemical measures and may be used to identify risk individuals for intensified preventive measures.
脂肪细胞动员脂肪酸（脂肪分解）对于能量消耗至关重要。脂肪分解既有自发性（基础）也有激素刺激的活性。目前尚不清楚脂肪分解对于未来体重增加和相关葡萄糖代谢紊乱是否重要，本研究在两个女性队列的皮下脂肪细胞中进行，这些脂肪细胞在≥10 年的随访前后进行了研究。高基础和低刺激脂肪分解在基线时预测未来体重增加（比值比≥4.6）以及胰岛素抵抗和空腹血糖受损/2 型糖尿病的发展（比值比≥3.2）。在基线时，体重增加者表现出几种已确立的脂肪分解调节基因的脂肪表达降低。因此，涉及基因表达改变的低效脂肪分解（高基础/低刺激）与未来体重增加和葡萄糖代谢受损有关，可能成为治疗靶点。最后，低刺激脂肪分解可以通过简单的临床/生化测量来准确估计体内，并可用于识别需要强化预防措施的风险个体。
