• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胃扩张预处理对大鼠肾缺血/再灌注损伤的保护作用

Protective Effect of Gastric Distension Preconditioning on Renal Ischemia/Reperfusion Injury in Rats.

作者信息

Malek M, Maleki M

机构信息

Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Iran.

Department of Physiology, School of Medicine, Ilam University of Medical Sciences, Ilam, Iran.

出版信息

Indian J Nephrol. 2018 Mar-Apr;28(2):113-118. doi: 10.4103/ijn.IJN_342_16.

DOI:10.4103/ijn.IJN_342_16
PMID:29861561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5952449/
Abstract

The stomach mechanoreceptors can be stimulated by gastric distension (GD) and through afferent vagal nerve, increased activity of the renal sympathetic pathways. Because renal sympathectomy can abolish the protective effect of ischemic preconditioning, it seems that GD preconditioning can be effective in renal ischemia/reperfusion (I/R) injury. Gastric inflate (8 ml of 37°C water for 20 min) by a latex balloon inserted into the stomach through the fundus; I/R group was subjected to 45 min of bilateral ischemia and 24 h of reperfusion. GD preconditioning decreases blood urea nitrogen, creatinine, kidney damage score, and alkaline phosphatase levels compared to the sham GD group ( < 0.05). GD preconditioning may protect renal I/R injury through anti-inflammatory activity, but this efficacy requires extensive studies on the methods and mechanisms.

摘要

胃机械感受器可被胃扩张（GD）刺激，并通过迷走神经传入，增加肾交感神经通路的活性。由于肾交感神经切除术可消除缺血预处理的保护作用，因此GD预处理似乎对肾缺血/再灌注（I/R）损伤有效。通过经胃底插入胃内的乳胶气球向胃内注入（37℃水8ml，持续20分钟）；I/R组经历45分钟的双侧缺血和24小时的再灌注。与假GD组相比，GD预处理可降低血尿素氮、肌酐、肾损伤评分和碱性磷酸酶水平（<0.05）。GD预处理可能通过抗炎活性保护肾I/R损伤，但这种疗效需要对方法和机制进行广泛研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/15c2514656e7/IJN-28-113-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/5257815bdcaf/IJN-28-113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/6f5a4b6010e7/IJN-28-113-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/5468057dd0ef/IJN-28-113-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/5ba2994cd146/IJN-28-113-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/173d61bf5334/IJN-28-113-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/15c2514656e7/IJN-28-113-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/5257815bdcaf/IJN-28-113-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/6f5a4b6010e7/IJN-28-113-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/5468057dd0ef/IJN-28-113-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/5ba2994cd146/IJN-28-113-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/173d61bf5334/IJN-28-113-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e7/5952449/15c2514656e7/IJN-28-113-g006.jpg

相似文献

1
Protective Effect of Gastric Distension Preconditioning on Renal Ischemia/Reperfusion Injury in Rats.胃扩张预处理对大鼠肾缺血/再灌注损伤的保护作用
Indian J Nephrol. 2018 Mar-Apr;28(2):113-118. doi: 10.4103/ijn.IJN_342_16.
2
The protective effects of ischemic preconditioning on rats with renal ischemia-reperfusion injury and the effects on the expression of Bcl-2 and Bax.缺血预处理对肾缺血再灌注损伤大鼠的保护作用及其对Bcl-2和Bax表达的影响。
Exp Ther Med. 2017 Nov;14(5):4077-4082. doi: 10.3892/etm.2017.5047. Epub 2017 Aug 28.
3
Protective effect of ischemic preconditioning on ischemia/reperfusion-induced acute kidney injury through sympathetic nervous system in rats.缺血预处理通过大鼠交感神经系统对缺血/再灌注诱导的急性肾损伤的保护作用。
Eur J Pharmacol. 2013 Oct 15;718(1-3):206-12. doi: 10.1016/j.ejphar.2013.08.032. Epub 2013 Sep 12.
4
Ischemic preconditioning, the most effective gastroprotective intervention: involvement of prostaglandins, nitric oxide, adenosine and sensory nerves.缺血预处理，最有效的胃保护干预措施：前列腺素、一氧化氮、腺苷和感觉神经的参与
Eur J Pharmacol. 2001 Sep 21;427(3):263-76. doi: 10.1016/s0014-2999(01)01246-8.
5
Ischemic preconditioning attenuates gastric ischemia-reperfusion injury through involvement of glucocorticoids.缺血预处理通过涉及糖皮质激素来减轻胃缺血再灌注损伤。
J Physiol Pharmacol. 2009 Dec;60 Suppl 7:155-60.
6
Ischemic preconditioning reduces the severity of ischemia/reperfusion-induced pancreatitis.缺血预处理可减轻缺血/再灌注诱导的胰腺炎的严重程度。
Eur J Pharmacol. 2003 Jul 25;473(2-3):207-16. doi: 10.1016/s0014-2999(03)01994-0.
7
Protective effects of renal ischemic preconditioning and adenosine pretreatment: role of A(1) and A(3) receptors.肾缺血预处理和腺苷预处理的保护作用：A(1)和A(3)受体的作用。
Am J Physiol Renal Physiol. 2000 Mar;278(3):F380-7. doi: 10.1152/ajprenal.2000.278.3.F380.
8
Role of nitric oxide in the renal protective effects of ischemic preconditioning.一氧化氮在缺血预处理肾脏保护作用中的角色。
J Cardiovasc Pharmacol. 2003 Sep;42(3):419-27. doi: 10.1097/00005344-200309000-00014.
9
Effects of Ischemic Preconditioning and Postconditioning in a Renal Ischemia-Reperfusion Injury Model: A Comparative Experimental Study in Rats.缺血预处理和后处理在肾缺血再灌注损伤模型中的作用：大鼠的一项对比实验研究
Transplant Proc. 2018 Dec;50(10):3811-3815. doi: 10.1016/j.transproceed.2018.07.021. Epub 2018 Nov 27.
10
Effect of ischemia preconditioning on renal ischemia/reperfusion injury in rats.缺血预处理对大鼠肾缺血/再灌注损伤的影响。
Int Braz J Urol. 2012 Nov-Dec;38(6):842-54. doi: 10.1590/1677-553820133806842.

引用本文的文献

1
Nephrogenic acute respiratory distress syndrome: A narrative review on pathophysiology and treatment.肾源性急性呼吸窘迫综合征：关于病理生理学和治疗的叙述性综述
Chin J Traumatol. 2018 Feb;21(1):4-10. doi: 10.1016/j.cjtee.2017.07.004. Epub 2017 Nov 24.

本文引用的文献

1
Ischemic preconditioning ameliorates intestinal injury induced by ischemia-reperfusion in rats.缺血预处理可改善大鼠缺血再灌注所致的肠道损伤。
World J Gastroenterol. 2015 Jul 14;21(26):8081-8. doi: 10.3748/wjg.v21.i26.8081.
2
Hypoxic Conditioning as a New Therapeutic Modality.低氧适应作为一种新的治疗方式。
Front Pediatr. 2015 Jun 22;3:58. doi: 10.3389/fped.2015.00058. eCollection 2015.
3
Renal ischemia/reperfusion injury; from pathophysiology to treatment.肾缺血/再灌注损伤：从病理生理学到治疗
J Renal Inj Prev. 2015 Jun 1;4(2):20-7. doi: 10.12861/jrip.2015.06. eCollection 2015.
4
Hyperoxia-induced preconditioning against renal ischemic injury is mediated by reactive oxygen species but not related to heat shock proteins 70 and 32.高氧诱导的肾缺血损伤预处理由活性氧介导，但与热休克蛋白70和32无关。
Surgery. 2015 Jun;157(6):1014-22. doi: 10.1016/j.surg.2015.01.025. Epub 2015 Apr 3.
5
The preventive effects of diminazene aceturate in renal ischemia/reperfusion injury in male and female rats.乙酰马啉对雄性和雌性大鼠肾缺血/再灌注损伤的预防作用。
Adv Prev Med. 2014;2014:740647. doi: 10.1155/2014/740647. Epub 2014 Nov 13.
6
Heat shock preconditioning protects against ER stress-induced apoptosis through the regulation of the BH3-only protein BIM.热休克预处理通过调控仅含BH3结构域的蛋白BIM来保护细胞免受内质网应激诱导的凋亡。
FEBS Open Bio. 2014 Sep 17;4:813-21. doi: 10.1016/j.fob.2014.09.004. eCollection 2014.
7
Dietary antioxidant and anti-inflammatory intake modifies the effect of cadmium exposure on markers of systemic inflammation and oxidative stress.饮食中的抗氧化剂和抗炎物质的摄入可以调节镉暴露对全身炎症和氧化应激标志物的影响。
Environ Res. 2014 May;131:6-12. doi: 10.1016/j.envres.2014.02.003. Epub 2014 Mar 5.
8
Ischemic preconditioning in the animal kidney, a systematic review and meta-analysis.动物肾脏中的缺血预处理：系统评价和荟萃分析。
PLoS One. 2012;7(2):e32296. doi: 10.1371/journal.pone.0032296. Epub 2012 Feb 28.
9
Lipopolysaccharide-induced preconditioning against ischemic injury is associated with changes in toll-like receptor 4 expression in the rat developing brain.脂多糖诱导的缺血性损伤预处理与大鼠发育脑 toll 样受体 4 表达的变化有关。
Pediatr Res. 2011 Jul;70(1):10-4. doi: 10.1203/PDR.0b013e31821d02aa.
10
Outcome predictability of serum alkaline phosphatase in men with pre-dialysis CKD.男性透析前 CKD 患者血清碱性磷酸酶的预后预测性。
Nephrol Dial Transplant. 2010 Sep;25(9):3003-11. doi: 10.1093/ndt/gfq144. Epub 2010 Mar 17.