Effect of over MSG-induced reproductive toxicity w.s.r. ovary and follicle count.

INTRODUCTION

Monosodium glutamate (MSG), an extensively used flavor enhancer, produces degenerative changes in cell and causes neural death which cause imbalance in endocrine system and disturb the body system. While taking consideration of its potency and affinity, it falls under the category of , which leads to various diseases among which is one and can be correlated with disturbance in reproductive system which may be endocrinological or related to gametes. (DVA) is a herbomineral formulation which is mentioned for the treatment of .

AIM

The aim is to evaluate the efficacy of DVA in MSG-induced female reproductive toxicity in Wistar rats.

MATERIALS AND METHODS

DVA was prepared and analyzed for preliminary physicochemical, organic and inorganic tests. Twenty-four rats were divided into four groups. Up to 14 days, MSG (0.20g/kg) was given to all groups except control group. From days 15 to 42, DVA (216mg/200g) was given to the third group and in the fourth group no intervention was given to evaluate auto recovery. The second group was considered as disease control. At the end, Follicle-stimu`lating hormone test and histopathology of ovary were done.

RESULTS

There was a significant increase in primary follicle count and decrease in atretic follicle count in DVA group. Secondary follicle count, tertiary follicle count and Graafian follicle count were increased in DVA group but the increase was not statistically significant.

CONCLUSION

MSG mainly acts as a neurotoxic component by oxidative stress. Mostly, the ingredients of DVA have anti-oxidant properties, which counteract the oxidative stress caused by MSG in cell. Many ingredients such as , and have neuroprotective property which corrects the neurodegeneration and balances the endocrine system.