一种阿育吠陀解毒剂杜希维沙里解毒剂对卡铂诱导的雄性Wistar大鼠骨髓抑制的影响。

Effect of an Ayurveda antidote Dooshivishari Agada in carboplatin induced myelosuppression in Male Wistar rats.

作者信息

Patil Santosh F, Shahapurkar Vishalaxi V, Khanal Pukar

机构信息

Department of Agadatantra, KLEU Shri B M K Ayurveda Mahavidyalaya, Nath Pai Circle, Shahpur, Belagavi, Karnataka, 590003, India.

Department of Agadatantra, Shivalik Ayurveda Medical College, Azamgrah, Uttarpradesh, India.

出版信息

J Ayurveda Integr Med. 2022 Jul-Sep;13(3):100599. doi: 10.1016/j.jaim.2022.100599. Epub 2022 Jul 18.

DOI:10.1016/j.jaim.2022.100599

PMID:35863084

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9304609/

Abstract

BACKGROUND

Carboplatin is one of the common chemotherapeutic agents in the management of various malignant conditions. Myelosuppression remains one of the major adverse effects of it that leads to compromised quality of life and can procrastinate or cease the chemotherapy regimen. Increasing shreds of evidence suggest the role of Complementary and alternate medicine in palliative cancer care. Ayurveda has prescribed Dooshivishari Agada (DVA) as an anti-dote for similar conditions mentioned above which arise out of sub-lethal toxic substances called Dooshivisha (DV).

OBJECTIVE

The present study was carried out to evaluate the role of DVA in myelosuppression among rats.

METHOD

Male Wistar rats weighing 250-275 g were divided into three groups, Group I was administered normal saline and acted as Normal control. Group II and III received a single dose of carboplatin (60 mg/kg through the tail vein) on day one and acted as disease control. Group III received experimental drug DVA 256 mg/kg orally for the next 18 days. Animals were bled on days 0, 3, 6, 9, 12, 15, 18 for hematological analysis.

RESULTS

DVA prolonged the nadir time for Hb, RBC, and WBC counts from day 9 to day 12 when compared to the carboplatin group. In terms of Platelet count, there was no significant difference over carboplatin. Group III showed a significant increase in Total reticulocyte count in comparison to group II.

CONCLUSION

Present study showed that DVA may help in delaying the myelosuppression which needs further evaluation.

摘要

背景

卡铂是治疗各种恶性疾病的常用化疗药物之一。骨髓抑制仍然是其主要不良反应之一，会导致生活质量下降，并可能拖延或中断化疗方案。越来越多的证据表明补充和替代医学在癌症姑息治疗中的作用。阿育吠陀医学已将杜希维沙里阿加达（DVA） prescribed 作为上述由称为杜希维沙（DV）的亚致死性有毒物质引起的类似病症的解毒剂。

目的

本研究旨在评估DVA对大鼠骨髓抑制的作用。

方法

将体重250 - 275克的雄性Wistar大鼠分为三组，第一组给予生理盐水作为正常对照。第二组和第三组在第1天接受单次卡铂剂量（通过尾静脉注射60毫克/千克）作为疾病对照。第三组在接下来的18天内口服实验药物DVA 256毫克/千克。在第0、3、6、9、12、15、18天对动物进行采血以进行血液学分析。