Klemmt Petra A B, Starzinski-Powitz Anna
Department of Molecular Cell Biology and Human Genetics, Institute of Cell Biology and Neuroscience, Johann Wolfgang Goethe University of Frankfurt, Max-von-Laue-Str. 13, D-60438Frankfurt am Main, Germany.
Curr Womens Health Rev. 2018 Jun;14(2):106-116. doi: 10.2174/1573404813666170306163448.
A substantial body of studies supports the view that molecular and cellular features of endometriotic lesions differ from those of eutopic endometrium. Apart from that, evidence exists that the eutopic endometrium from pa-tients with endometriosis differs from that of females without endometriosis.
Aberrant expression profiles include a number of non-steroid signaling pathways that exert their putative influ-ence on the pathogenesis of endometriosis at least in part via crosstalk(s) with estrogen-mediated mechanisms. A rational to focus research on non-steroid signal pathways is that they might be remunerative targets for the development and selection of novel therapeutics to treat endometriosis possibly without affecting estrogen levels.
In this article, we describe molecular and cellular features of endometriotic lesions and focus on the canonical WNT/β-signaling pathway, a key regulatory system in biology (including stem cell homeostasis) and often in pathophysiological conditions such as endometriosis. Recently emerged novel biological concepts in signal transduction and gene regulation like exosomes and microRNAs are discussed in their putative role in the pathogenesis of endometriosis.
大量研究支持这样一种观点，即子宫内膜异位症病灶的分子和细胞特征与在位内膜不同。除此之外，有证据表明，子宫内膜异位症患者的在位内膜与无子宫内膜异位症女性的在位内膜也存在差异。
异常表达谱包括一些非甾体信号通路，这些信号通路至少部分通过与雌激素介导的机制相互作用，对子宫内膜异位症的发病机制产生假定影响。将研究重点放在非甾体信号通路上的一个理由是，它们可能是开发和选择新型治疗药物的有利靶点，有望在不影响雌激素水平的情况下治疗子宫内膜异位症。
在本文中，我们描述了子宫内膜异位症病灶的分子和细胞特征，并重点关注经典的WNT/β信号通路，这是生物学（包括干细胞稳态）中的关键调节系统，在诸如子宫内膜异位症等病理生理状况中也常发挥作用。文中还讨论了信号转导和基因调控领域最近出现的新生物学概念，如外泌体和微小RNA在子宫内膜异位症发病机制中的假定作用。
