Chowdhury Mohammed M, Tawakol Ahmed, Jaffer Farouc A
Division of Vascular & Endovascular Surgery, Department of Surgery, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
Division of Cardiology, Massachusetts General Hospital; Harvard Medical School; Boston, Massachusetts.
Curr Cardiovasc Imaging Rep. 2017 Jan;10(1). doi: 10.1007/s12410-017-9397-1. Epub 2017 Feb 4.
Molecular imaging of cardiovascular disease is a powerful clinical and experimental approach that can inform our understanding of atherosclerosis biology. Complementing cross-sectional imaging techniques that provide detailed anatomical information, molecular imaging can further detect important biological changes occurring within atheroma, and refine the prediction of vascular complications. In addition, molecular imaging of atherosclerosis can illuminate underlying pathophysiology and serve as a surrogate end-point in clinical trials of new drugs. This review showcases promising molecular approaches for imaging atherosclerosis, with a focus on PET, MRI, and intravascular near-infrared fluorescence (NIRF) imaging methods that are in the clinic or close-to-clinical usage.
心血管疾病的分子成像技术是一种强大的临床和实验方法，有助于我们理解动脉粥样硬化生物学。与提供详细解剖信息的横断面成像技术相辅相成，分子成像能够进一步检测动脉粥样硬化斑块内发生的重要生物学变化，并优化对血管并发症的预测。此外，动脉粥样硬化的分子成像可以阐明潜在的病理生理学机制，并在新药临床试验中作为替代终点。本综述展示了用于动脉粥样硬化成像的有前景的分子方法，重点关注正电子发射断层扫描（PET）、磁共振成像（MRI）以及已应用于临床或接近临床应用的血管内近红外荧光（NIRF）成像方法。
