动脉粥样硬化的分子成像：临床聚焦
Molecular Imaging of Atherosclerosis: A Clinical Focus.
作者信息
Chowdhury Mohammed M, Tawakol Ahmed, Jaffer Farouc A
机构信息
Division of Vascular & Endovascular Surgery, Department of Surgery, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
Division of Cardiology, Massachusetts General Hospital; Harvard Medical School; Boston, Massachusetts.
出版信息
Curr Cardiovasc Imaging Rep. 2017 Jan;10(1). doi: 10.1007/s12410-017-9397-1. Epub 2017 Feb 4.
Abstract
Molecular imaging of cardiovascular disease is a powerful clinical and experimental approach that can inform our understanding of atherosclerosis biology. Complementing cross-sectional imaging techniques that provide detailed anatomical information, molecular imaging can further detect important biological changes occurring within atheroma, and refine the prediction of vascular complications. In addition, molecular imaging of atherosclerosis can illuminate underlying pathophysiology and serve as a surrogate end-point in clinical trials of new drugs. This review showcases promising molecular approaches for imaging atherosclerosis, with a focus on PET, MRI, and intravascular near-infrared fluorescence (NIRF) imaging methods that are in the clinic or close-to-clinical usage.
摘要
心血管疾病的分子成像技术是一种强大的临床和实验方法，有助于我们理解动脉粥样硬化生物学。与提供详细解剖信息的横断面成像技术相辅相成，分子成像能够进一步检测动脉粥样硬化斑块内发生的重要生物学变化，并优化对血管并发症的预测。此外，动脉粥样硬化的分子成像可以阐明潜在的病理生理学机制，并在新药临床试验中作为替代终点。本综述展示了用于动脉粥样硬化成像的有前景的分子方法，重点关注正电子发射断层扫描（PET）、磁共振成像（MRI）以及已应用于临床或接近临床应用的血管内近红外荧光（NIRF）成像方法。
相似文献
1
Molecular Imaging of Atherosclerosis: A Clinical Focus.动脉粥样硬化的分子成像：临床聚焦
Curr Cardiovasc Imaging Rep. 2017 Jan;10(1). doi: 10.1007/s12410-017-9397-1. Epub 2017 Feb 4.
2
Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis: Clinical and Intracoronary Evaluation of Indocyanine Green.动脉粥样硬化的靶向近红外荧光成像：吲哚菁绿的临床及冠状动脉内评估
JACC Cardiovasc Imaging. 2016 Sep;9(9):1087-1095. doi: 10.1016/j.jcmg.2016.01.034. Epub 2016 Aug 17.
3
Intravascular Molecular Imaging: Near-Infrared Fluorescence as a New Frontier.血管内分子成像：近红外荧光成为新前沿领域。
Front Cardiovasc Med. 2020 Nov 23;7:587100. doi: 10.3389/fcvm.2020.587100. eCollection 2020.
4
Metabolic and Molecular Imaging of Atherosclerosis and Venous Thromboembolism.动脉粥样硬化和静脉血栓栓塞的代谢与分子成像
J Nucl Med. 2017 Jun;58(6):871-877. doi: 10.2967/jnumed.116.182873. Epub 2017 Apr 27.
5
Fully integrated high-speed intravascular optical coherence tomography/near-infrared fluorescence structural/molecular imaging in vivo using a clinically available near-infrared fluorescence-emitting indocyanine green to detect inflamed lipid-rich atheromata in coronary-sized vessels.使用临床可用的近红外荧光发射吲哚菁绿在体内进行完全集成的高速血管内光学相干断层扫描/近红外荧光结构/分子成像，以检测冠状动脉大小血管中发炎的富含脂质的动脉粥样硬化斑块。
Circ Cardiovasc Interv. 2014 Aug;7(4):560-9. doi: 10.1161/CIRCINTERVENTIONS.114.001498. Epub 2014 Jul 29.
6
Validating Intravascular Imaging with Serial Optical Coherence Tomography and Confocal Fluorescence Microscopy.通过连续光学相干断层扫描和共聚焦荧光显微镜验证血管内成像
Int J Mol Sci. 2016 Dec 15;17(12):2110. doi: 10.3390/ijms17122110.
7
Intracoronary dual-modal optical coherence tomography-near-infrared fluorescence structural-molecular imaging with a clinical dose of indocyanine green for the assessment of high-risk plaques and stent-associated inflammation in a beating coronary artery.应用临床剂量吲哚菁绿的冠状动脉内双模光学相干断层成像-近红外荧光结构分子成像评估跳动冠状动脉高危斑块和支架相关炎症
Eur Heart J. 2016 Oct 1;37(37):2833-2844. doi: 10.1093/eurheartj/ehv726. Epub 2016 Jan 18.
8
Progress on multimodal molecular / anatomical intravascular imaging of coronary vessels combining near infrared fluorescence and ultrasound.结合近红外荧光和超声的冠状动脉多模态分子/解剖学血管内成像研究进展
Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:1117-20. doi: 10.1109/IEMBS.2011.6090261.
9
Future imaging of atherosclerosis: molecular imaging of coronary atherosclerosis with (18)F positron emission tomography.动脉粥样硬化的未来成像：利用（18）F正电子发射断层扫描对冠状动脉粥样硬化进行分子成像。
Cardiovasc Diagn Ther. 2016 Aug;6(4):354-67. doi: 10.21037/cdt.2015.12.02.
10
Intravascular NIRF Molecular Imaging Approaches in Coronary Artery Disease.冠状动脉疾病中的血管内近红外荧光分子成像方法
Curr Cardiovasc Imaging Rep. 2016 Apr;9. doi: 10.1007/s12410-016-9374-0. Epub 2016 Mar 7.
引用本文的文献
1
Targeting macrophages with multifunctional nanoparticles to detect and prevent atherosclerotic cardiovascular disease.利用多功能纳米颗粒靶向巨噬细胞检测和预防动脉粥样硬化性心血管疾病。
Cardiovasc Res. 2024 Jul 2;120(8):819-838. doi: 10.1093/cvr/cvae099.
2
Aiming at early-stage vulnerable plaques: A nanoplatform with dual-mode imaging and lipid-inflammation integrated regulation for atherosclerotic theranostics.针对早期易损斑块：一种用于动脉粥样硬化诊疗的具有双模态成像和脂质-炎症综合调控功能的纳米平台。
Bioact Mater. 2024 Mar 16;37:94-105. doi: 10.1016/j.bioactmat.2024.03.019. eCollection 2024 Jul.
3
Intravascular Fluorescence Molecular Imaging of Atherosclerosis.血管内荧光分子影像学在动脉粥样硬化中的应用。
Methods Mol Biol. 2022;2419:853-872. doi: 10.1007/978-1-0716-1924-7_52.
4
The Molecular Basis of Predicting Atherosclerotic Cardiovascular Disease Risk.预测动脉粥样硬化性心血管疾病风险的分子基础。
Circ Res. 2021 Jan 22;128(2):287-303. doi: 10.1161/CIRCRESAHA.120.315890. Epub 2021 Jan 21.
5
Intravascular Molecular Imaging: Near-Infrared Fluorescence as a New Frontier.血管内分子成像：近红外荧光成为新前沿领域。
Front Cardiovasc Med. 2020 Nov 23;7:587100. doi: 10.3389/fcvm.2020.587100. eCollection 2020.
6
Small Dimension-Big Impact! Nanoparticle-Enhanced Non-Invasive and Intravascular Molecular Imaging of Atherosclerosis In Vivo.小尺寸，大影响！纳米颗粒增强的体内动脉粥样硬化的非侵入性和血管内分子成像。
Molecules. 2020 Feb 25;25(5):1029. doi: 10.3390/molecules25051029.
本文引用的文献
1
Short-term changes in arterial inflammation predict long-term changes in atherosclerosis progression.动脉炎症的短期变化可预测动脉粥样硬化进展的长期变化。
Eur J Nucl Med Mol Imaging. 2017 Jan;44(1):141-150. doi: 10.1007/s00259-016-3524-0. Epub 2016 Oct 13.
2
Targeted Near-Infrared Fluorescence Imaging of Atherosclerosis: Clinical and Intracoronary Evaluation of Indocyanine Green.动脉粥样硬化的靶向近红外荧光成像：吲哚菁绿的临床及冠状动脉内评估
JACC Cardiovasc Imaging. 2016 Sep;9(9):1087-1095. doi: 10.1016/j.jcmg.2016.01.034. Epub 2016 Aug 17.
3
Hybrid intravascular imaging: recent advances, technical considerations, and current applications in the study of plaque pathophysiology.混合血管内成像：斑块病理生理学研究的最新进展、技术考量及当前应用
Eur Heart J. 2017 Feb 7;38(6):400-412. doi: 10.1093/eurheartj/ehw097.
4
Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction: A Randomized Clinical Trial.洛马司他莫在急性心肌梗死后住院患者中的心血管结局影响：一项随机临床试验。
JAMA. 2016 Apr 19;315(15):1591-9. doi: 10.1001/jama.2016.3609.
5
Clinical Characterization of Coronary Atherosclerosis With Dual-Modality OCT and Near-Infrared Autofluorescence Imaging.冠状动脉粥样硬化的双模态光学相干断层扫描和近红外自发荧光成像的临床特征
JACC Cardiovasc Imaging. 2016 Nov;9(11):1304-1314. doi: 10.1016/j.jcmg.2015.11.020. Epub 2016 Mar 9.
6
Positron Emission Tomography and Magnetic Resonance Imaging of Cellular Inflammation in Patients with Abdominal Aortic Aneurysms.腹主动脉瘤患者细胞炎症的正电子发射断层扫描和磁共振成像
Eur J Vasc Endovasc Surg. 2016 Apr;51(4):518-26. doi: 10.1016/j.ejvs.2015.12.018. Epub 2016 Feb 23.
7
Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis.用自身抗体对实验性动脉粥样硬化中氧化型低密度脂蛋白进行近红外荧光（NIRF）分子成像
Sci Rep. 2016 Feb 25;6:21785. doi: 10.1038/srep21785.
8
Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo.血管内纤维蛋白分子成像可改善通过光学相干断层扫描在体内评估未愈合支架的检测。
Eur Heart J. 2017 Feb 7;38(6):447-455. doi: 10.1093/eurheartj/ehv677. Epub 2015 Dec 18.
9
Comparison of Atherosclerotic Calcification in Major Vessel Beds on the Risk of All-Cause and Cause-Specific Mortality: The Rotterdam Study.主要血管床动脉粥样硬化钙化与全因死亡率和特定病因死亡率风险的比较：鹿特丹研究
Circ Cardiovasc Imaging. 2015 Dec;8(12). doi: 10.1161/CIRCIMAGING.115.003843.
10
64Cu-DOTATATE for Noninvasive Assessment of Atherosclerosis in Large Arteries and Its Correlation with Risk Factors: Head-to-Head Comparison with 68Ga-DOTATOC in 60 Patients.64Cu-DOTATATE 用于大动脉粥样硬化的无创评估及其与危险因素的相关性：60 例患者头对头比较与 68Ga-DOTATOC
J Nucl Med. 2015 Dec;56(12):1895-900. doi: 10.2967/jnumed.115.161216. Epub 2015 Oct 1.
Zotero 插件