Cardiology Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston (M.N., K.J.B.).
Sections of Preventive Medicine & Epidemiology, and Cardiology, Department of Medicine, Boston University School of Medicine, MA (R.S.V.).
Circ Res. 2021 Jan 22;128(2):287-303. doi: 10.1161/CIRCRESAHA.120.315890. Epub 2021 Jan 21.
Atherosclerotic cardiovascular disease (ASCVD) proceeds through a series of stages: initiation, progression (or regression), and complications. By integrating known biology regarding molecular signatures of each stage with recent advances in high-dimensional molecular data acquisition platforms (to assay the genome, epigenome, transcriptome, proteome, metabolome, and gut microbiome), snapshots of each phase of atherosclerotic cardiovascular disease development can be captured. In this review, we will summarize emerging approaches for assessment of atherosclerotic cardiovascular disease risk in humans using peripheral blood molecular signatures and molecular imaging approaches. We will then discuss the potential (and challenges) for these snapshots to be integrated into a personalized movie providing dynamic readouts of an individual's atherosclerotic cardiovascular disease risk status throughout the life course.
动脉粥样硬化性心血管疾病（ASCVD）经历了一系列阶段：起始、进展（或消退）和并发症。通过整合每个阶段的分子特征的已知生物学知识，以及最近在高维分子数据获取平台方面的进展（检测基因组、表观基因组、转录组、蛋白质组、代谢组和肠道微生物组），可以捕获动脉粥样硬化性心血管疾病发展的每个阶段的快照。在这篇综述中，我们将总结使用外周血分子特征和分子成像方法评估人类动脉粥样硬化性心血管疾病风险的新方法。然后，我们将讨论这些快照被整合到个性化电影中的潜力（和挑战），该电影可以提供个体整个生命过程中动脉粥样硬化性心血管疾病风险状况的动态读数。
