Zhu Xiao, Yu Haibing, Xiao Qin, Ke Jianhao, Li Hongmei, Chen Zhihong, Ding Hongrong, Leng Shuilong, Huang Yongmei, Zhan Jingting, Lei Jinli, Fan Wenguo, Luo Hui
Key Laboratory of Medical Molecular Diagnosis, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, China.
Institute of Bioinformatics, University of Georgia, Athens, GA, USA.
Oncotarget. 2018 May 18;9(38):24872-24881. doi: 10.18632/oncotarget.23791.
CHD5 is an essential factor for neuronal differentiation and neurodegenerative diseases. Here, the targeted next generation sequencing and TaqMan genotyping technologies were carried out for gene in a two-staged case-control study in Chinese population. The genetic statistics and gene-environment interactions were analyzed to find certain risk factors of Alzheimer's disease. We found intronic rs11121295 was associated with the risk of Alzheimer's disease at both stages including combined cohorts. This risk effect presented consistently significant associations with the alcoholic subgroups at both all stages in the stratified analysis. The gene-environment interactions further supported the above findings. Our study highlighted the potential role of variants in conferring susceptibility to sporadic Alzheimer's disease, especially modified its risk by alcoholic intake.
CHD5是神经元分化和神经退行性疾病的一个重要因素。在此，在中国人群的一项两阶段病例对照研究中，针对该基因开展了靶向新一代测序和TaqMan基因分型技术。分析了遗传统计学和基因-环境相互作用，以寻找阿尔茨海默病的某些风险因素。我们发现内含子rs11121295在包括合并队列的两个阶段均与阿尔茨海默病风险相关。在分层分析中，这种风险效应在所有阶段均与酒精摄入亚组呈现出一致的显著关联。基因-环境相互作用进一步支持了上述发现。我们的研究强调了这些变体在赋予散发性阿尔茨海默病易感性方面的潜在作用，尤其是酒精摄入会改变其风险。
