金催化的酰胺-醛-炔偶联及环化串联反应——2,4,5-三取代恶唑的合成
Gold-catalyzed tandem reactions of amide-aldehyde-alkyne coupling and cyclization-synthesis of 2,4,5-trisubstituted oxazoles.
作者信息
Querard Pierre, Girard Simon A, Uhlig Nick, Li Chao-Jun
机构信息
Department of Chemistry , FQRNT Center for Green Chemistry and Catalysis , McGill University , 801 Sherbrooke Street West , Montreal , Quebec H3A 0B8 , Canada . Email:
出版信息
Chem Sci. 2015 Dec 1;6(12):7332-7335. doi: 10.1039/c5sc02933c. Epub 2015 Oct 6.
Abstract
We report the first cationic gold(i)-catalyzed one-pot reaction of amide, alkyne and aldehyde followed by cyclization, to successfully access highly substituted oxazoles derivatives in good yields. A single catalyst allows the occurring of this multi-step reaction atom- and step-economically, with water as the only theoretical side product.
摘要
我们报道了首例阳离子金（I）催化的酰胺、炔烃和醛的一锅法反应，随后进行环化反应，以良好的产率成功合成了高度取代的恶唑衍生物。单一催化剂能使这一多步反应以原子经济性和步骤经济性的方式进行，水是唯一的理论副产物。
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