通过金（I）催化的氧化/1,2-炔基迁移/环化串联反应合成高度取代的N-（呋喃-3-基亚甲基）苯磺酰胺
Synthesis of highly substituted N-(furan-3-ylmethylene)benzenesulfonamides by a gold(I)-catalyzed oxidation/1,2-alkynyl migration/cyclization cascade.
作者信息
Wang Tao, Huang Long, Shi Shuai, Rudolph Matthias, Hashmi A Stephen K
机构信息
Organisch-Chemisches Institut, Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, 69120 Heidelberg (Germany), Fax: (+49) 6221-54-4205.
出版信息
Chemistry. 2014 Nov 3;20(45):14868-71. doi: 10.1002/chem.201404229. Epub 2014 Sep 18.
PMID:25236914
Abstract
A variety of N-(furan-3-ylmethylene)benzenesulfonamides were obtained by a gold(I)-catalyzed cascade reaction from easily accessible starting materials. The reaction pathway involves a rarely observed 1,2-alkynyl migration onto a gold carbenoid. This observation further enriches gold carbenoid chemistry with regard to group migration.
摘要
通过金（I）催化的串联反应，从易于获得的起始原料中得到了多种N-（呋喃-3-基亚甲基）苯磺酰胺。反应途径涉及一种罕见的1,2-炔基迁移到金卡宾上。这一发现进一步丰富了金卡宾化学中关于基团迁移的内容。
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