Aquino Rachael K, Perez Michael, Sil Payel, Shintani Terry, Harrigan Rosanne, Rodriguez Beatriz
Department of Geriatrics and Department of Complementary and Alternative Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.
National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA.
Geriatrics (Basel). 2018 Jun;3(2). doi: 10.3390/geriatrics3020017. Epub 2018 Apr 4.
In 2010, approximately 79 million Americans had prediabetes and about 50 percent of those individuals were 65 years and older. The most effective diabetes prevention method in prediabetic adults is lifestyle modification. However, despite the benefits of lifestyle change, diabetes prevalence continues to increase. Maintaining a regular exercise routine and a healthy eating plan may be difficult because of the negative emotional barriers (i.e., stress, mood) that a prediabetic individual faces. This is particularly evident in older individuals when you combine that with decreases in mobility and geriatric syndromes. A potential treatment for these emotional barriers is a natural supplement called 5-aminolevulinic acid (5-ALA). In the current study, the group included 154 participants, both men and women, ranging between the ages of 41 to 71 years old. The study design was a double-blind, randomized parallel-group study. The Psychosocial Depressive Symptoms Questionnaire (PDS) and the Perceived Stress Scale (PSS) were used to examine the effect of two doses of 5-ALA (15 mg and 50 mg) on various components of mood (i.e., hopefulness, loneliness, and motivation) and coping ability. Using SAS software, an ordered logistic regression model was used to analyze the association between the dose groups (control, 15 mg, and 50 mg) and the responses to the two questionnaires, the PDS and PSS, used in this study. An integrative literature review, using the PubMed database, searched for studies on the relationship between 5-ALA administration and mood and coping ability. Our literature review resulted in zero published articles. Next, we found that the intake of 5-ALA was significantly associated with improved coping ability ( = 0.004) and improved self-perception of effort spent ( = 0.002). Finally, we found a significant dose-dependent relationship for the association of 5-ALA intake on measures of effort ( = 0.003), loneliness ( = 0.006), and coping ability ( = 0.003). The 50 mg dose was more effective than the 15 mg dose in improving these measures. In conclusion, after 12 weeks of taking 5-ALA, we found significant improvements in self-perception of effort spent, loneliness, and coping ability in prediabetic middle age and older adults. Improved mood and coping ability may allow prediabetic individuals to overcome the emotional obstacles preventing them from maintaining a healthy lifestyle and ultimately, help them to avoid the development of diabetes.
2010年，约7900万美国人患有糖尿病前期，其中约50%为65岁及以上人群。糖尿病前期成年人最有效的糖尿病预防方法是改变生活方式。然而，尽管改变生活方式有诸多益处，但糖尿病患病率仍在持续上升。由于糖尿病前期个体面临负面情绪障碍（如压力、情绪），保持规律的锻炼习惯和健康的饮食计划可能会很困难。当与行动能力下降和老年综合征相结合时，这在老年人中尤为明显。一种名为5-氨基乙酰丙酸（5-ALA）的天然补充剂可能是治疗这些情绪障碍的方法。在本研究中，该组包括154名参与者，男女皆有，年龄在41至71岁之间。研究设计为双盲、随机平行组研究。使用心理社会抑郁症状问卷（PDS）和感知压力量表（PSS）来检验两剂5-ALA（15毫克和50毫克）对情绪的各个组成部分（如希望、孤独和动力）及应对能力的影响。使用SAS软件，采用有序逻辑回归模型分析剂量组（对照组、15毫克组和50毫克组）与本研究中使用的两份问卷（PDS和PSS）的反应之间的关联。通过使用PubMed数据库进行综合文献综述，搜索关于5-ALA给药与情绪和应对能力之间关系的研究。我们的文献综述未找到已发表的文章。接下来，我们发现摄入5-ALA与应对能力的改善（P = 0.004）和对所花费努力的自我认知的改善（P = 0.002）显著相关。最后，我们发现5-ALA摄入量与努力程度（P = 0.003）、孤独感（P = 0.006）和应对能力（P = 0.003）的测量结果之间存在显著的剂量依赖性关系。50毫克剂量在改善这些指标方面比15毫克剂量更有效。总之，在服用5-ALA 12周后，我们发现糖尿病前期的中年和老年人在对所花费努力的自我认知、孤独感和应对能力方面有显著改善。情绪和应对能力的改善可能使糖尿病前期个体克服阻碍他们保持健康生活方式的情绪障碍，并最终帮助他们避免患糖尿病。
