Association between and Gene Polymorphisms and the Risk of Diabetic Kidney Disease in Patients with Type 2 Diabetes in a Chinese Han Population.

Single-nucleotide polymorphisms (SNPs) in gene regions have been reported to be associated with diabetic kidney disease (DKD) in the American population. We examined the association between polymorphisms in and DKD susceptibility in a Chinese Han population. rs3752462 (T>C) and rs136161 (C>G) were genotyped in 303 DKD patients and 364 type 2 diabetes mellitus (T2DM) patients without kidney disease using the TaqMan SNP genotyping assay. Chi-squared test and multivariate logistic regression were used to evaluate the association. We observed that only rs3752462 was associated with DKD (genotype, = 0.004; allele, = 0.002). Genetic model analysis revealed that rs3752462 was associated with increased risk of DKD under a dominant model adjusted by age and sex (adjusted odds ratio (aOR), 1.675; 95% CI 1.225-2.289; = 0.001) and an additive model (TC versus TT: aOR, 1.649; 95% CI 1.187-2.290; CC versus TT: aOR, 1.817; 95% CI 0.980-3.367; = 0.005). The combined effect of rs3752462 TC + rs136161 CC genotype showed an association of DKD adjusted by age and sex (aOR, 1.732; 95% CI 1.128-2.660; = 0.012). After a Holm-Bonferroni correction for multiple tests, the C allele frequencies of the rs3752462 and the TC + CC genotype in the dominant model were considered statistically significant with a markedly increased risk of DKD ( < 0.00208; < 0.002). Our results suggest that rs3752462 is significantly associated with an increased risk of DKD in Chinese Han individuals.