Setti Sharay E, Hunsberger Holly C, Reed Miranda N
Department of Drug Discovery & Development, Auburn University.
Department of Psychiatry, Columbia University.
Transl Issues Psychol Sci. 2017 Dec;3(4):348-356. doi: 10.1037/tps0000124.
The aging population and those with amnestic mild cognitive impairment (aMCI) are at increased risk for developing Alzheimer's disease (AD). Individuals with aMCI in particular may display pathological changes in brain function that may ultimately result in a diagnosis of AD. This review focuses specifically on hippocampal hyperexcitability, a pathology that is sometimes detectable years before diagnosis, which has been observed in individuals with aMCI. We describe how changes in hippocampal activity are associated with, or in some cases may be permissive for, the development of AD. Finally, we describe how lifestyle changes, including exercise and dietary changes can attenuate cognitive decline and hippocampal hyperexcitability, potentially reducing the risk of developing AD.
老龄化人口以及患有遗忘型轻度认知障碍（aMCI）的人群患阿尔茨海默病（AD）的风险增加。特别是患有aMCI的个体可能会出现脑功能的病理变化，最终可能导致AD的诊断。本综述特别关注海马体过度兴奋，这是一种有时在诊断前数年就能检测到的病理状态，在患有aMCI的个体中已经观察到。我们描述了海马体活动的变化如何与AD的发展相关联，或者在某些情况下可能促进AD的发展。最后，我们描述了生活方式的改变，包括运动和饮食变化如何减轻认知衰退和海马体过度兴奋，从而潜在地降低患AD的风险。
