海马体活动改变与阿尔茨海默病
Alterations in Hippocampal Activity and Alzheimer's Disease.
作者信息
Setti Sharay E, Hunsberger Holly C, Reed Miranda N
机构信息
Department of Drug Discovery & Development, Auburn University.
Department of Psychiatry, Columbia University.
出版信息
Transl Issues Psychol Sci. 2017 Dec;3(4):348-356. doi: 10.1037/tps0000124.
Abstract
The aging population and those with amnestic mild cognitive impairment (aMCI) are at increased risk for developing Alzheimer's disease (AD). Individuals with aMCI in particular may display pathological changes in brain function that may ultimately result in a diagnosis of AD. This review focuses specifically on hippocampal hyperexcitability, a pathology that is sometimes detectable years before diagnosis, which has been observed in individuals with aMCI. We describe how changes in hippocampal activity are associated with, or in some cases may be permissive for, the development of AD. Finally, we describe how lifestyle changes, including exercise and dietary changes can attenuate cognitive decline and hippocampal hyperexcitability, potentially reducing the risk of developing AD.
摘要
老龄化人口以及患有遗忘型轻度认知障碍（aMCI）的人群患阿尔茨海默病（AD）的风险增加。特别是患有aMCI的个体可能会出现脑功能的病理变化，最终可能导致AD的诊断。本综述特别关注海马体过度兴奋，这是一种有时在诊断前数年就能检测到的病理状态，在患有aMCI的个体中已经观察到。我们描述了海马体活动的变化如何与AD的发展相关联，或者在某些情况下可能促进AD的发展。最后，我们描述了生活方式的改变，包括运动和饮食变化如何减轻认知衰退和海马体过度兴奋，从而潜在地降低患AD的风险。
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本文引用的文献
1
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Nat Neurosci. 2016 Aug;19(8):1085-92. doi: 10.1038/nn.4328. Epub 2016 Jun 20.
2
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Nat Commun. 2016 Mar 21;7:10962. doi: 10.1038/ncomms10962.
3
Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity.通过神经活动的化学遗传调控减轻β-淀粉样蛋白沉积和神经毒性
J Neurosci. 2016 Jan 13;36(2):632-41. doi: 10.1523/JNEUROSCI.2531-15.2016.
4
Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice.自愿运动可减轻脂多糖诱导的老年小鼠神经发生减少，并增加小胶质细胞促神经发生表型的表达。
J Neuroinflammation. 2015 Jul 30;12:138. doi: 10.1186/s12974-015-0362-0.
5
Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression.利鲁唑可挽救与P301L tau蛋白表达相关的谷氨酸改变、认知缺陷和tau蛋白病理变化。
J Neurochem. 2015 Oct;135(2):381-94. doi: 10.1111/jnc.13230. Epub 2015 Aug 13.
6
P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway.P301L tau 表达影响海马三突触通路中谷氨酸的释放和清除。
J Neurochem. 2015 Jan;132(2):169-82. doi: 10.1111/jnc.12967. Epub 2014 Oct 31.
7
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Epilepsia. 2014 Nov;55(11):1817-25. doi: 10.1111/epi.12797. Epub 2014 Sep 29.
8
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9
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