手性金属有机骨架催化的反式-β-硝基苯乙烯与 N,N-二烷基苯胺的高对映选择性 Friedel-Crafts 烷基化反应。
Highly enantioselective Friedel-Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal-organic framework.
机构信息
Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Suita, Osaka 564-8680, Japan.
出版信息
Chem Commun (Camb). 2018 Jun 14;54(49):6328-6331. doi: 10.1039/c8cc03447h.
PMID:29862390
Abstract
The first enantioselective Friedel-Crafts alkylation of N,N-dialkylanilines with trans-β-nitrostyrene catalyzed by a homochiral metal-organic framework constructed from (R)-2,2'-dihydroxy-1,1'-binaphthyl-6,6'-dicarboxylic acid has been developed. The reaction proceeded in high yields (∼96%) with excellent enantioselectivities (∼98% ee).
摘要
已开发出由(R)-2,2'-二羟基-1,1'-联萘-6,6'-二甲酸构建的手性金属有机骨架，用于催化 N,N-二烷基苯胺与反式-β-硝基苯乙烯的首例对映选择性 Friedel-Crafts 烷基化反应。该反应以高产率（约 96%）和优异的对映选择性（约 98%ee）进行。
Zotero 插件