Christov Florian, Nelson Erik G, Gluth Michael B
1 University of Chicago Section of Otolaryngology-Head & Neck Surgery, Chicago Illinois, USA, and Universitaetsklinikum Essen, Essen, Germany.
2 University of Chicago, Bloom Otopathology Laboratory, Chicago, Illinois, USA.
Ann Otol Rhinol Laryngol. 2018 Aug;127(8):527-535. doi: 10.1177/0003489418779405. Epub 2018 Jun 4.
Normative data on superior olivary nucleus neuron counts derived from human specimens are sparse, and little is known about their coherence with structure and function of the cochlea. The purpose of this study was to quantify the neuron populations of the divisions of the superior olivary nucleus in human subjects with normal hearing and presbycusis and investigate potential relationships between these findings and histopathology in the cochlea and hearing phenotype Methods: Histopathologic examination of temporal bone and brainstem specimens from 13 subjects having normal hearing or presbycusis was undertaken. The following was determined for each: number and density of superior olivary nucleus and cochlear nucleus neurons, inner and outer hair cell counts, spiral ganglion cell counts, and pure tone audiometry.
The results demonstrate a significant relationship between cells within structures of the cochlear nucleus and the number of neurons of the medial superior olivary nucleus. No relationship between superior olivary nucleus neuron counts/density and cochlear histopathology or hearing phenotype was encountered.
Normative data for superior olivary nucleus neuron populations are further established in the data presented in this study that includes subjects with normal hearing and also presbycusis.
源自人体标本的上橄榄核神经元计数的规范数据稀少，且对于它们与耳蜗结构和功能的相关性知之甚少。本研究的目的是量化听力正常和患有老年性耳聋的人类受试者中上橄榄核各部分的神经元数量，并研究这些结果与耳蜗组织病理学及听力表型之间的潜在关系。方法：对13名听力正常或患有老年性耳聋的受试者的颞骨和脑干标本进行组织病理学检查。对每个标本测定以下内容：上橄榄核和耳蜗核神经元的数量和密度、内毛细胞和外毛细胞计数以及螺旋神经节细胞计数，以及纯音听力测定。
结果表明，耳蜗核结构内的细胞与内侧上橄榄核神经元数量之间存在显著关系。未发现上橄榄核神经元计数/密度与耳蜗组织病理学或听力表型之间存在关系。
本研究提供的数据进一步确立了上橄榄核神经元群体的规范数据，该数据涵盖了听力正常和患有老年性耳聋的受试者。
