Gautier Guillaume, Roch Nathalie, Karsenty Judith, Bailly Henri, Ogier-Desserrey Agathe, Goux Alain, Martha Benoît, Podac Bianca
Laboratoire de biologie médicale.
Service de maladies infectieuses.
Ann Biol Clin (Paris). 2018 Jun 1;76(3):336-343. doi: 10.1684/abc.2018.1345.
Meningitis and septicaemia due to Capnocytophaga canimorsus are extremely rare and described as emerging zoonoses because of their low incidence and prevalence, but also because of the challenges in bacterial identification, thus, the real number of cases is probably underestimated. We report the case of a 61-year-old man, with a history a chronic alcoholism, who developed, following a recent dog bite, meningitis with normoglycorachia and concomitant sepsis, and had a favorable outcome after intravenous probabilistic antibiotherapy combining ceftazidime and metronidazole. This association aimed to cover the risks represented by Pseudomonas spp and anaerobic bacteria, once the microorganisms commonly associated with meningitis were excluded using molecular biology tools. In addition to the unusual biological results (normoglycorachia and bacterial morphology after Gram staining), we present the biological diagnostic approach (molecular, biochemical and physical tools successively used to lead, by exclusion and confirmation, to this diagnosis), closely linked to the clinical expertise. This is, to our knowledge, the first described case of meningitis with normoglycorachia and septicaemia due to Capnocytophaga canimorsus successfully treated with ceftazidime and confirmed by identification by MALDI-TOF mass spectrometry.
犬咬二氧化碳嗜纤维菌所致的脑膜炎和败血症极为罕见,因其发病率和患病率低,且细菌鉴定存在挑战,所以被视为新发人畜共患病,因此实际病例数可能被低估。我们报告一例61岁男性病例,该患者有慢性酒精中毒史,近期被狗咬伤后发生了血糖正常的脑膜炎并伴有败血症,在静脉注射头孢他啶和甲硝唑联合的经验性抗生素治疗后预后良好。一旦使用分子生物学工具排除了常见的与脑膜炎相关的微生物,这种联合用药旨在应对由假单胞菌属和厌氧菌所带来的风险。除了不寻常的生物学结果(血糖正常和革兰氏染色后的细菌形态)外,我们还展示了生物学诊断方法(分子、生化和物理工具相继用于通过排除和确认得出该诊断),这与临床专业知识密切相关。据我们所知,这是首例因犬咬二氧化碳嗜纤维菌导致血糖正常的脑膜炎和败血症,经头孢他啶成功治疗并通过基质辅助激光解吸电离飞行时间质谱鉴定确诊的病例。