Department of Infectious Diseases, Charles University School of Medicine and Faculty Hospital, Hradec Kralove, Czech Republic.
Department of Clinical Microbiology, Charles University School of Medicine and Faculty Hospital, Hradec Kralove, Czech Republic.
BMC Infect Dis. 2020 Feb 3;20(1):100. doi: 10.1186/s12879-020-4760-2.
Invasive infections caused by Capnocytophaga canimorsus are rare. Immunocompromised patients, who report being bitten by or having a close contact with an animal, represent a high-risk group for this infection. There are only few dozens of infections by this bacteria manifesting as purulent meningitis reported worldwide. The reported case is a first reported case of purulent meningitis caused by by Capnocytophaga canimorsus in Czech Republic with only a limited risk factor history.
The patient, a 74 years old man, was referred to the infectious diseases department of a teaching hospital with clear signs of developing purulent meningitis. His anamnestic data did not show any unusual findings. He was treated for compensated diabetes mellitus type II. The blood cultures were negative and the etiological agent did not grow from the cerebrospinal fluid (CSF) on common media. Eventually, it was identified by detecting pan-bacterial DNA and DNA sequencing. Subsequently, the pathogen was confirmed by anaerobic cultivation from CSF. Only after then the patient recalled being bitten by his German shepherd puppy during play. The patient was successfully treated intravenously by ceftriaxone.
Purulent meningitis caused by Capnocytophaga spp. is a rare disease, but it needs to be considered in patients at risk with pre-existing conditions, who report close contact with or being bitten by an animal. It is important to test for this microbe in cases with negative microbiological results for the more common agents.
犬齿戈特里亚菌引起的侵袭性感染较为罕见。免疫功能低下的患者，有动物咬伤或密切接触动物的报告，是这种感染的高危人群。全世界报告的由这种细菌引起的化脓性脑膜炎感染仅有几十例。该报告病例为捷克共和国首例报告的犬齿戈特里亚菌引起的化脓性脑膜炎，仅有有限的危险因素史。
患者，一名 74 岁男性，因明显化脓性脑膜炎表现被转诊至教学医院传染病科。其病史无任何异常发现。他正在接受 2 型代偿性糖尿病治疗。血培养为阴性，且常见培养基未从脑脊液（CSF）中培养出病原体。最终，通过检测泛细菌 DNA 和 DNA 测序发现了病原体。随后，通过从 CSF 进行厌氧培养确认了病原体。直到那时，患者才回忆起在玩耍时被他的德国牧羊犬小狗咬伤。患者通过头孢曲松静脉治疗成功治愈。
由犬齿戈特里亚菌引起的化脓性脑膜炎是一种罕见疾病，但对于有基础疾病、有动物咬伤或密切接触动物的高危患者，需要考虑该病。在常见病原体的微生物学检测结果为阴性的情况下，检测这种微生物很重要。
