研究新生儿缺氧缺血性脑病时 IGF-1、GH 和 NGB 水平变化与 NBNA 评分的相关性。
Study on the correlation of changes of IGF-1, GH, and NGB levels and NBNA score in neonates with hypoxic ischemic encephalopathy.
机构信息
Department of Neonatal, Xuzhou Children's Hospital, Xuzhou, Jangsu, China.
出版信息
Eur Rev Med Pharmacol Sci. 2018 May;22(10):3173-3181. doi: 10.26355/eurrev_201805_15078.
OBJECTIVE
The aim of this work was to investigate the correlation between dynamic changes of serum insulin-like growth factor 1 (IGF-1), growth hormone (GH), neuroglobin (NGB), and neonatal behavioral neurological assessment (NBNA) scores in different periods in neonates with hypoxic ischemic encephalopathy (HIE).
PATIENTS AND METHODS
Sixty HIE patients in the Neonatal Department of our hospital were selected. They were divided into the mild group (35 cases), moderate group (19 cases), and severe group (six cases) according to the diagnostic criteria. During the same period, 18 neonatal patients born at term in our hospital were chosen as the control group. Data were analyzed by SPSS19.0 statistical software (SPSS Inc., Chicago, IL, USA). The dynamic changes of IGF-1, GH, and NGB in different periods, as well as NBNA scores in HIE patients and in the control group, were analyzed. Furthermore, we analyzed the degree of correlation of IGF-1, GH, and NGB in different periods as well as NBNA scores in HIE patients and in the control group.
RESULTS
1- IGF-1 levels between the three groups of HIE patients and control group had significant differences (p<0.05); 2- Comparing GH levels between the HIE experimental groups and control group, there was no statistical significance; 3-Comparing serum NGB levels between the three HIE experimental groups and control group, there were significant differences (p<0.05); 4- Comparing NBNA scores of the three groups of HIE patients and control group, there was a significant difference between the mild group and control group; 5- Serum IGF-1 and NBNA scores were positively correlated in the acute and recovery phase, while NGB level and NBNA scores were negatively correlated in the acute and recovery phase (p<0.05), which had statistical significance.
CONCLUSIONS
In neonatal HIE, serum IGF-1, GH, and NGB levels change. IGF-1 and NGB levels correlate with the prognosis of HIE.
目的
本研究旨在探讨新生儿缺氧缺血性脑病（HIE）患儿不同时期血清胰岛素样生长因子 1（IGF-1）、生长激素（GH）、神经球蛋白（NGB）与新生儿行为神经测定（NBNA）评分的相关性。
方法
选取我院新生儿科收治的 HIE 患儿 60 例，根据诊断标准分为轻度组（35 例）、中度组（19 例）和重度组（6 例），同时选取同期我院足月出生的 18 例新生儿为对照组。采用 SPSS19.0 统计软件（SPSS Inc.，Chicago，IL，USA）进行数据分析。分析 HIE 患儿及对照组不同时期 IGF-1、GH、NGB 动态变化及 NBNA 评分，并分析 HIE 患儿及对照组不同时期 IGF-1、GH、NGB 之间的相关性以及 NBNA 评分的相关性。
结果
- HIE 患儿三组与对照组 IGF-1 水平比较，差异有统计学意义（p<0.05）；2. HIE 实验组与对照组 GH 水平比较，差异无统计学意义；3. HIE 三组与对照组血清 NGB 水平比较，差异有统计学意义（p<0.05）；4. HIE 三组患儿与对照组 NBNA 评分比较，差异有统计学意义（p<0.05）；5. 血清 IGF-1 与 NBNA 评分在急性期和恢复期呈正相关，而 NGB 水平与 NBNA 评分在急性期和恢复期呈负相关（p<0.05），差异均有统计学意义。
结论
新生儿 HIE 时血清 IGF-1、GH、NGB 水平发生变化，IGF-1、NGB 水平与 HIE 预后相关。
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