State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy , China Pharmaceutical University , Nanjing 210009 , P. R. China.
Org Lett. 2018 Jun 15;20(12):3477-3481. doi: 10.1021/acs.orglett.8b01235. Epub 2018 Jun 4.
A novel strategy for intercepting the σ-alkylpalladium species generated via a Heck reaction, enabling a palladium-catalyzed cyclization of o-ethynylanilines, has been described. This direct and operationally simple protocol provided a fundamental platform to synthesize bisindoles with high efficiency, involving one C-N bond and two C-C bond formations.
一种新策略用于拦截 Heck 反应生成的 σ-烷基钯物种，实现了邻炔基苯胺的钯催化环化反应。该直接且操作简单的方案为高效合成双吲哚类化合物提供了一个基本平台，涉及到一个 C-N 键和两个 C-C 键的形成。
