Zhu Qingqiang, Zhu Wenrong, Ye Jing, Wu Jingtao, Chen Wenxin, Hao Zhihua
1 Department of Medical Imaging, Subei People's Hospital, Medical School of Yangzhou University, Yangzhou, PR China.
2 Hebei General Hospital, Shijiazhuang, PR China.
Acta Radiol. 2019 Mar;60(3):382-387. doi: 10.1177/0284185118778884. Epub 2018 Jun 4.
Few studies have reported on the use of intravoxel incoherent motion (IVIM) for renal tumors.
To investigate the value of IVIM for distinguishing renal tumors.
Thirty-one patients with clear cell renal cell carcinomas (CCRCCs), 13 patients with renal angiomyolipomas with minimal fat (RAMFs), eight patients with chromophobe renal cell carcinomas (ChRCCs), and ten patients with papillary renal cell carcinomas (PRCCs) were examined. The tissue diffusivity (D), pseudodiffusivity (D*), and perfusion fraction (f) were calculated.
The D and f values were highest for CCRCCs, lowest for PRCCs, and intermediate for ChRCCs and RAMFs ( P < 0.05). The D values of CCRCCs differed significantly from those of ChRCCs and PRCCs ( P < 0.05). The D* values were highest for RAMFs, lowest for ChRCCs, and intermediate for CCRCCs and PRCCs ( P < 0.05). Statistically significant differences were observed between the D* values of CCRCCs and RAMFs ( P < 0.05). The D* values of the CCRCCs differed significantly from the D* values of the ChRCCs ( P < 0.05). Using the D and f values of 1.10 and 0.41, respectively, as the threshold values for differentiating CCRCCs from RAMFs, ChRCCs, and PRCCs, the best results had sensitivities of 81.0% and 66.8% and specificities of 85.7% and 81.0%, respectively. Using the D* value of 0.038 as the threshold value for differentiating RAMFs from CCRCCs, ChRCCs, and PRCCs, the best result obtained had a sensitivity of 90.5% and specificity of 76.2%.
IVIM may provide information for differentiating renal tumor types.
很少有研究报道体素内不相干运动（IVIM）在肾肿瘤中的应用。
探讨IVIM在鉴别肾肿瘤中的价值。
对31例透明细胞肾细胞癌（CCRCC）患者、13例脂肪含量极少的肾血管平滑肌脂肪瘤（RAMF）患者、8例嫌色细胞肾细胞癌（ChRCC）患者和10例乳头状肾细胞癌（PRCC）患者进行检查。计算组织扩散率（D）、假扩散率（D*）和灌注分数（f）。
CCRCC的D值和f值最高，PRCC最低，ChRCC和RAMF居中（P < 0.05）。CCRCC的D值与ChRCC和PRCC的D值有显著差异（P < 0.05）。RAMF的D值最高，ChRCC最低，CCRCC和PRCC居中（P < 0.05）。CCRCC与RAMF的D值存在统计学显著差异（P < 0.05）。CCRCC的D值与ChRCC的D值有显著差异（P < 0.05）。分别将D值1.10和f值0.41作为区分CCRCC与RAMF、ChRCC和PRCC的阈值，最佳结果的敏感度分别为81.0%和66.8%，特异度分别为85.7%和81.0%。将D*值0.038作为区分RAMF与CCRCC、ChRCC和PRCC的阈值，获得的最佳结果敏感度为90.5%，特异度为76.2%。
IVIM可为鉴别肾肿瘤类型提供信息。
