[作为口蹄疫病毒灭活剂的双乙烯亚胺]
[Binary ethyleneimine as an inactivator of the foot-and-mouth disease virus].
作者信息
Tekerlekov P, Veleva E
出版信息
Vet Med Nauki. 1985;22(3):3-8.
PMID:2986348
Abstract
Experiments were carried out to inactivate F.M.D. viruses with the use of binary ethylene-imine. It was found that inactivation was optimal when the agent was used at the rate of 0.003 M for 18 hours at 26 degrees C. Its neutralization in the virus suspension was carried out with 3 mM sodium thiosulfate. The inactivated F.M.D. viruses retained their complement-fixing and immunogenic properties. Discussed are the advantages of using binary ethyleneimine as an inactivating agent as against other agents of the asiridine order.
摘要
进行了使用双乙烯亚胺灭活口蹄疫病毒的实验。发现当该试剂以0.003 M的浓度在26℃下使用18小时时，灭活效果最佳。在病毒悬液中用3 mM硫代硫酸钠对其进行中和。灭活后的口蹄疫病毒保留了其补体结合特性和免疫原性。讨论了与氮丙啶类的其他试剂相比，使用双乙烯亚胺作为灭活剂的优点。
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