抗A组红细胞的人单克隆抗体。
Human monoclonal antibodies against group A red blood cells.
作者信息
Raubitschek A, Senyk G, Larrick J, Lizak G, Foung S
出版信息
Vox Sang. 1985;48(5):305-8. doi: 10.1111/j.1423-0410.1985.tb00186.x.
Abstract
A human monoclonal antibody with anti-A specificity was generated by Epstein-Barr virus transformation of lymphocytes isolated from splenic tissue after in vitro stimulation with group A red blood cells. This antibody is of the IgM class and directly agglutinates group A red blood cells. Type A1, A2, Aint, A3, AX, Aend and A5 cells were agglutinated by the reagent indicating a single determinant is shared by these A subgroups.
摘要
通过用 A 组红细胞进行体外刺激后，从脾组织分离的淋巴细胞经 Epstein-Barr 病毒转化产生了一种具有抗 A 特异性的人单克隆抗体。该抗体属于 IgM 类，可直接凝集 A 组红细胞。试剂能凝集 A1、A2、Aint、A3、AX、Aend 和 A5 型细胞，表明这些 A 亚群共享一个单一决定簇。
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