Author Affiliations: School of Nursing (Drs Jung, Crandell, Palmer, Bryant, and Mayer), School of Medicine (Dr Nielsen), and Lineberger Comprehensive Cancer Center (Drs Nielsen, Bryant, and Mayer), The University of North Carolina at Chapel Hill; and School of Nursing, Duke University, Durham, North Carolina (Dr Smith).
Cancer Nurs. 2019 May/Jun;42(3):E21-E33. doi: 10.1097/NCC.0000000000000606.
Non-muscle-invasive bladder cancer (NMIBC) represents approximately 75% of newly diagnosed patients with bladder cancer. Non-muscle-invasive bladder cancer survivors have unique chronic burdens including frequent recurrences, repeated surveillance cystoscopies and treatments, and the highest lifetime medical cost per person among all cancers.
The purpose of this study was to summarize studies assessing quality of life (QOL) in NMIBC survivors.
The literature from January 2005 to March 2017 found in PubMed, CINAHL, and PsycINFO databases was reviewed systematically. Inclusion criteria were as follows: (1) research about NMIBC survivors, (2) outcomes included QOL, (3) original research article published in peer-reviewed journals, and (4) published in English.
A total of 15 studies were included: 14 quantitative studies and 1 mixed-methods study. Non-muscle-invasive bladder cancer survivors had significantly lower QOL compared with the general population, especially in fatigue, physical and role functioning, and mental health. Repeated transurethral resections and intravesical treatments were associated with impaired physical function and mental health. Most NMIBC survivors had concerns of urinary and bowel problems and sexual function.
Despite a good prognosis, NMIBC and its treatment have a significant impact on QOL in survivors. The findings showed large burdens in NMIBC survivors and suggest that further research is needed to better understand potential opportunities to improve QOL in this population.
Oncology nurses are in the critical position for assessing symptoms and concerns. Oncology nurses should pay special attention to NMIBC survivors who have unique symptoms and burden with the aim of improving survivors' QOL.
非肌层浸润性膀胱癌（NMIBC）约占新诊断膀胱癌患者的 75%。非肌层浸润性膀胱癌幸存者存在独特的慢性负担，包括频繁复发、反复进行膀胱镜检查和治疗，以及所有癌症中每人终生医疗费用最高。
本研究旨在总结评估 NMIBC 幸存者生活质量（QOL）的研究。
系统地回顾了 2005 年 1 月至 2017 年 3 月间在 PubMed、CINAHL 和 PsycINFO 数据库中找到的文献。纳入标准如下：（1）研究对象为 NMIBC 幸存者，（2）结局指标包括 QOL，（3）为同行评议期刊发表的原始研究文章，（4）以英文发表。
共纳入 15 项研究：14 项定量研究和 1 项混合方法研究。与一般人群相比，非肌层浸润性膀胱癌幸存者的 QOL 明显较低，尤其是在疲劳、身体和角色功能以及心理健康方面。反复经尿道切除术和膀胱内治疗与身体功能和心理健康受损有关。大多数 NMIBC 幸存者对尿和肠道问题以及性功能存在担忧。
尽管预后良好，但膀胱癌及其治疗对幸存者的 QOL 有重大影响。研究结果表明 NMIBC 幸存者负担沉重，表明需要进一步研究，以更好地了解改善这一人群 QOL 的潜在机会。
肿瘤护士在评估症状和问题方面处于关键地位。肿瘤护士应特别关注有独特症状和负担的 NMIBC 幸存者，以提高幸存者的 QOL。
