Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering , East China Normal University , 3663 N. Zhongshan Road , Shanghai 200062 , P. R. China.
Org Lett. 2018 Jun 15;20(12):3587-3590. doi: 10.1021/acs.orglett.8b01378. Epub 2018 Jun 4.
A highly efficient and stereoselective synthesis of enantioenriched imidazolidines by rhodium-catalyzed intermolecular [3 + 2] cycloaddition reaction of chiral vinyl aziridines and oxime ethers has been successfully developed. Notably, both aldoximes and ketoximes are suitable substrates to afford the corresponding chiral imidazolidines in high yields with good stereoselectivity. This transformation represents an unprecedented example that utilizes ketimine derivatives as an aza-[2C]-component in cycloadditions of vinyl aziridines.
通过手性乙烯基氮丙啶与肟醚的铑催化的分子间[3+2]环加成反应，成功地开发了一种高效和立体选择性的手性咪唑烷的合成方法。值得注意的是，醛肟和酮肟都是合适的底物，以高产率和良好的立体选择性得到相应的手性咪唑烷。这种转化代表了利用亚胺衍生物作为乙烯基氮丙啶环加成的aza-[2C]-组分的空前实例。
