KSO/TEMPO 诱导的级联氧化环化/缺电子基团 1,2-迁移：构建 1H-吡咯-2(3H)-酮的策略。
KSO/TEMPO-Induced Cascade Oxidative Cyclization/1,2-Migration of Electron-Deficient Groups: Strategy for the Construction of 1 H-Pyrrol-2(3 H)-ones.
机构信息
Shaanxi Key Laboratory of Phytochemistry, College of Chemistry and Chemical Engineering , Baoji University of Arts and Sciences , Baoji , Shaanxi 721013 , P. R. China.
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science , Northwest University , Xi'an 710127 , P. R. China.
出版信息
Org Lett. 2018 Jun 15;20(12):3627-3630. doi: 10.1021/acs.orglett.8b01402. Epub 2018 Jun 4.
A KSO/TEMPO-induced oxidative cyclization of N-unprotected enaminoesters and enaminones that gave 1 H-pyrrol-2(3 H)-ones in good yields with broad functional group compatibility is reported. This method provides easy access to 1,2-carbon migration of ester or acyl group under transition-metal-free conditions.
本文报道了 KSO/TEMPO 诱导的 N-未保护的烯胺酯和烯胺的氧化环化反应，该反应以良好的收率和广泛的官能团兼容性得到了 1 H-吡咯-2(3 H)-酮。该方法在无过渡金属条件下提供了酯基或酰基 1,2-迁移的简便途径。
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