Ngwenya Laura B, Gardner Raquel C, Yue John K, Burke John F, Ferguson Adam R, Huang Michael C, Winkler Ethan A, Pirracchio Romain, Satris Gabriela G, Yuh Esther L, Mukherjee Pratik, Valadka Alex B, Okonkwo David O, Manley Geoffrey T
a Department of Neurosurgery , University of Cincinnati , Cincinnati , OH , USA.
b Department of Neurology and Rehabilitation Medicine , University of Cincinnati , Cincinnati , OH , USA.
Brain Inj. 2018;32(9):1071-1078. doi: 10.1080/02699052.2018.1481527. Epub 2018 Jun 4.
To determine characteristics and concordance of subjective cognitive complaints (SCCs) 6 months following mild-traumatic brain injury (mTBI) as assessed by two different TBI common data elements (CDEs).
The Transforming Research and Clinical Knowledge in Traumatic Brain Injury (TRACK-TBI) Pilot Study was a prospective observational study that utilized the NIH TBI CDEs, Version 1.0. We examined variables associated with SCC, performance on objective cognitive tests (Wechsler Adult Intelligence Scale, California Verbal Learning Test, and Trail Making Tests A and B), and agreement on self-report of SCCs as assessed by the acute concussion evaluation (ACE) versus the Rivermead Post Concussion Symptoms Questionnaire (RPQ).
In total, 68% of 227 participants endorsed SCCs at 6 months. Factors associated with SCC included less education, psychiatric history, and being assaulted. Compared to participants without SCC, those with SCC defined by RPQ performed significantly worse on all cognitive tests. There was moderate agreement between the two measures of SCCs (kappa = 0.567 to 0.680).
We show that the symptom questionnaires ACE and RPQ show good, but not excellent, agreement for SCCs in an mTBI study population. Our results support the retention of RPQ as a basic CDE for mTBI research.
BSI-18: Brief Symptom Inventory; 18CDEs: common data elements; CT: computed tomography; CVLT: California Verbal Learning Test; ED: emergency department; GCS: Glasgow coma scale; LOC: loss of consciousnessm; TBI: mild-traumatic brain injury; PTA: post-traumatic amnesia; SCC: subjective cognitive complaints; TBI: traumatic brain injury; TRACK-TBI: Transforming Research and Clinical Knowledge in Traumatic Brain Injury; TMT: Trail Making Test; WAIS-PSI: Wechsler Adult Intelligence Scale, Fourth Edition, Processing Speed Index.
通过两种不同的创伤性脑损伤通用数据元素（CDE）评估，确定轻度创伤性脑损伤（mTBI）后6个月主观认知主诉（SCC）的特征及一致性。
创伤性脑损伤转化研究与临床知识（TRACK-TBI）试点研究是一项前瞻性观察性研究，采用了美国国立卫生研究院（NIH）创伤性脑损伤CDE第1.0版。我们研究了与SCC相关的变量、客观认知测试（韦氏成人智力量表、加利福尼亚言语学习测试以及连线测验A和B）的表现，以及急性脑震荡评估（ACE）与Rivermead脑震荡后症状问卷（RPQ）对SCC自我报告评估的一致性。
227名参与者中，共有68%在6个月时认可存在SCC。与SCC相关的因素包括受教育程度较低、有精神病史以及遭受攻击。与无SCC的参与者相比，由RPQ定义为有SCC的参与者在所有认知测试中的表现明显更差。两种SCC测量方法之间存在中度一致性（kappa = 0.567至0.680）。
我们表明，在mTBI研究人群中，症状问卷ACE和RPQ对SCC显示出良好但非极佳的一致性。我们的结果支持保留RPQ作为mTBI研究的基本CDE。
BSI-18：简明症状量表；18CDEs：通用数据元素；CT：计算机断层扫描；CVLT：加利福尼亚言语学习测试；ED：急诊科；GCS：格拉斯哥昏迷量表；LOC：意识丧失；TBI：轻度创伤性脑损伤；PTA：创伤后遗忘；SCC：主观认知主诉；TBI：创伤性脑损伤；TRACK-TBI：创伤性脑损伤转化研究与临床知识；TMT：连线测验；WAIS-PSI：韦氏成人智力量表第四版加工速度指数
