Department of Emergency Medicine, University of Cincinnati, Cincinnati, Ohio, USA.
Biostatistics Research Center, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, California, USA.
J Neurotrauma. 2021 Dec;38(23):3352-3363. doi: 10.1089/neu.2020.7546. Epub 2021 Oct 18.
It is important to measure quality of life (QoL) after traumatic brain injury (TBI), yet limited studies have compared QoL inventories. In 2579 TBI patients, orthopedic trauma controls, and healthy friend control participants, we compared the Quality of Life After Brain Injury-Overall Scale (QOLIBRI-OS), developed for TBI patients, to the Satisfaction with Life Scale (SWLS), an index of generic life satisfaction. We tested the hypothesis that group differences (TBI and orthopedic trauma vs. healthy friend controls) would be larger for the QOLIBRI-OS than the SWLS and that the QOLIBRI-OS would manifest more substantial changes over time in the injured groups, demonstrating more relevance of the QOLIBRI-OS to traumatic injury recovery. (1) We compared the group differences (TBI vs. orthopedic trauma control vs. friend control) in QoL as indexed by the SWLS versus the QOLIBRI-OS and (2) characterized changes across time in these two inventories across 1 year in these three groups. Our secondary objective was to characterize the relationship between TBI severity and QoL. As compared with healthy friend controls, the QOLIBRI reflected greater reductions in QoL than the SWLS for both the TBI group (all time points) and the orthopedic trauma control group (2 weeks and 3 months). The QOLIBRI-OS better captured expected improvements in QoL during the injury recovery course in injured groups than the SWLS, which demonstrated smaller changes over time. TBI severity was not consistently or robustly associated with self-reported QoL. The findings imply that, as compared with the SWLS, the QOLIBRI-OS appears to identify QoL issues more specifically relevant to traumatically injured patients and may be a more appropriate primary QoL outcome measure for research focused on the sequelae of traumatic injuries.
衡量创伤性脑损伤（TBI）后的生活质量（QoL）很重要，但比较 QoL 量表的研究有限。在 2579 例 TBI 患者、骨科创伤对照和健康朋友对照参与者中，我们比较了专为 TBI 患者开发的脑损伤后生活质量总体量表（QOLIBRI-OS）与生活满意度量表（SWLS），后者是一般生活满意度的指标。我们检验了以下假设：与 SWLS 相比，TBI 和骨科创伤组与健康朋友对照组之间的组间差异（TBI 和骨科创伤组与健康朋友对照组）将更大，并且在受伤组中，QOLIBRI-OS 随时间的推移会发生更显著的变化，从而证明 QOLIBRI-OS 与创伤性损伤恢复的相关性更强。（1）我们比较了 SWLS 与 QOLIBRI-OS 索引的 QoL 在 TBI 组与骨科创伤对照组与朋友对照组之间的组间差异，（2）在这三个组中，在 1 年内，在这两个量表中描述了随时间的变化。我们的次要目标是描述 TBI 严重程度与 QoL 的关系。与健康朋友对照组相比，在所有时间点，TBI 组和骨科创伤对照组的 QOLIBRI 反映出 QoL 降低幅度大于 SWLS。在受伤组的损伤恢复过程中，QOLIBRI-OS 比 SWLS 更好地捕捉到了 QoL 的预期改善，后者随时间的变化较小。TBI 严重程度与自我报告的 QoL 之间没有一致或稳健的相关性。研究结果表明，与 SWLS 相比，QOLIBRI-OS 似乎更能准确识别与创伤性损伤患者更相关的 QoL 问题，并且可能是更适合关注创伤性损伤后果的研究的主要 QoL 结局测量方法。
